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[Systemic lupus erythematosus involving the fornix column leading to hyponatremia: A case report].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2024
Department of Rheumatology, Peking University Third Hospital, Beijing 100191, China.
We reported the diagnostic and therapeutic process of a young male patient with systemic lupus erythematosus (SLE) who presented with severe hyponatremia as the main manifestation upon admission, and analyzed and discussed the case. The patient was a 19-year-old young male with a subacute course of disease, fever ≥38.3 ℃ that could not be explained by other causes, acute and subacute cutaneous lupus erythematosus, oral ulcers, arthritis, leukopenia (< 4×10/L), low C3+low C4, and positive anti-double-stranded DNA (anti-dsDNA).
View Article and Find Full Text PDFHyponatremia in Critically Ill Patients Due to Continuous Venovenous Hemofiltration With Diluted Sodium Citrate.
ASAIO J
October 2024
From the Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Continuous venovenous hemofiltration (CVVH) is frequently performed in critically ill patients using diluted citrate for regional anticoagulation. The impact of this renal replacement strategy on plasma sodium has not been evaluated yet. Our aim was therefore to assess the period prevalence of hyponatremia (sodium <135 mmol/L) during CVVH and discuss possible underlying mechanisms.
View Article and Find Full Text PDFImplications of Dysnatremia and Endocrine Disturbances in COVID-19 Patients.
Int J Mol Sci
September 2024
Clinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Centre Osijek, 4 Josip Huttler Street, HR-31000 Osijek, Croatia.
Article Synopsis
- - Sodium imbalance is a frequent issue in COVID-19, often caused by hormonal disruptions, particularly involving conditions like hypothyroidism and hypocortisolism, which can both lead to lower sodium levels (hyponatremia).
- - Hypocortisolism, resulting from adrenal or pituitary issues, affects the kidneys' ability to excrete water properly and increases the secretion of antidiuretic hormone (ADH), further diluting sodium levels.
- - The review emphasizes that the relationship between COVID-19 and sodium imbalance is complicated by factors like the renin-angiotensin-aldosterone system (RAAS) being impacted by the virus, highlighting the need for more research to better manage these disturbances in affected
Sterile water and regional citrate anticoagulation: A simple CRRT strategy for safe correction of severe hyponatraemia.
Nurs Crit Care
November 2024
Department of Critical Care Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Article Synopsis
- Hyponatraemia, a common issue in critically ill patients, can worsen if low sodium levels are corrected too quickly using continuous renal replacement therapy (CRRT), risking osmotic demyelination syndrome (ODS), which this study seeks to prevent through individualized treatment methods.
- This retrospective case series involved four ICU patients with severe hyponatraemia and renal failure, where CRRT was used together with sterile water and regional citrate anticoagulation (RCA) to gradually correct sodium levels while monitoring for adverse effects.
- Results showed a significant increase in sodium levels post-treatment, with no complications related to CRRT, suggesting that this protocol is a safe and effective way to address severe hyponatraemia, easily implementable by
Pathophysiology of Hyponatremia in Preterm Infants with Relative Adrenal Insufficiency after the Early Neonatal Period.
Am J Perinatol
September 2024
Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Objective: Preterm infants often develop relative adrenal insufficiency (RAI) not only within the early neonatal period but also beyond this period. RAI is commonly accompanied by hyponatremia, but the pathogenesis of hyponatremia with RAI has not been clarified. This study aimed to investigate the pathophysiology of hyponatremia in infants with RAI.
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