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Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against using integrated computational approaches.
Front Vet Sci
January 2025
Department of Zoology, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan.
, responsible for flea-borne spotted fever, is a rising zoonotic pathogen posing an increasing global threat due to its expanding geographical distribution. The rise in antibiotic-resistant strains of this pathogen underscores the urgent need for new therapeutic interventions. This study employed a comprehensive subtractive proteomics analysis of the proteome, aiming to identify essential, non-host homologous, and pathogen-specific proteins, which were subsequently evaluated as potential new drug targets.
View Article and Find Full Text PDFLignin and Peptide Promote the Abundance and Activity of Arsenic Methylation Microbes in Paddy Soils.
Environ Sci Technol
January 2025
Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Rice physiological straighthead disease is induced by microbially mediated arsenic methylation and usually regionally distributed in paddy soils. However, the biogeochemical mechanism underlying the geographic distribution of microbial communities harboring methylating genes () remains unclear. Herein, we revealed significant ( = 0.
View Article and Find Full Text PDFReporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors.
Future Sci OA
December 2025
Janssen Research & Development LLC, Raritan, NJ, USA.
Background: Including racial and ethnic minorities in clinical trials is essential for advancing health equity. Despite progress, trials often do not mirror patient population demographics.
Methods: The National Library of Medicine's Clinical Trials database was queried for phase III trials of lung, colorectal, breast, and prostate cancers.
Equilibrium study of logistics demand and logistics resource allocation in Guangdong Province.
Sci Rep
January 2025
Desautels Faculty of Management, McGill University, Montreal, QC, Canada.
Logistics serve as a vital link between production and consumption. The balanced allocation of logistics demand and resources can promote the harmonious development of the logistics system, thereby fostering regional economic growth. As a leading region in China's reform and opening-up, Guangdong Province has experienced high economic growth.
View Article and Find Full Text PDFHistorical biogeography of the Mugil cephalus species complex and its rapid global colonization.
Mol Phylogenet Evol
January 2025
MARBEC, Univ Montpellier, CNRS, Ifremer, IRD, cc093, Place E. Bataillon, 34095 Montpellier Cedex 05, France.
Our understanding of speciation processes in marine environments remains very limited and the role of different reproductive barriers are still debated. While physical barriers were considered important drivers causing reproductive isolation, recent studies highlight the importance of climatic and hydrological changes creating unsuitable habitat conditions as factors promoting population isolation. Although speciation in marine fish has been investigated from different perspectives, these studies often have a limited geographical extant.
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