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Does Executive Functioning Moderate the Association Between Psychopathic Traits and Antisocial Behavior in Youth?
Res Child Adolesc Psychopathol
January 2025
Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA, USA.
This study examined the interplay of psychopathic traits, executive functioning, and antisocial behavior among adjudicated youth, with a focus on the potential moderating role of executive function. The current study uses data from the Pathways to Desistance dataset was examined, utilizing the Psychopathy Checklist: Youth Version (PCL-YV) and the Stroop Color-Word Task to measure psychopathic traits and executive functioning, respectively. Violent and property offending frequencies were self-reported.
View Article and Find Full Text PDFChromosome-level assembly of basil genome unveils the genetic variation driving Genovese and Thai aroma types.
Plant J
January 2025
Unit of Aromatic and Medicinal Plants, Newe Ya'ar Research Center, Volcani Institute, Ramat-Yishay, Israel.
Basil, Ocimum basilicum L., is a widely cultivated aromatic herb, prized for its culinary and medicinal uses, predominantly owing to its unique aroma, primarily determined by eugenol for Genovese cultivars or methyl chavicol for Thai cultivars. To date, a comprehensive basil reference genome has been lacking, with only a fragmented draft available.
View Article and Find Full Text PDFAstrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress.
Epigenetics
December 2025
Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
The effects of chronically stressing male mice can be transmitted across generations by stress-specific changes in their sperm miRNA content, which induce stress-specific phenotypes in their offspring. However, how each stress paradigm alters the levels of distinct sets of sperm miRNAs is not known. We showed previously that exposure of male mice to chronic social instability (CSI) stress results in elevated anxiety and reduced sociability specifically in their female offspring across multiple generations because it reduces miR-34c levels in sperm of stressed males and their unstressed male offspring.
View Article and Find Full Text PDFGenetic prediction of complex traits, enabled by large-scale genomic studies, has created new measures to understand individual genetic predisposition. Polygenic Risk Scores (PRS) offer a way to aggregate information across the genome, enabling personalized risk prediction for complex traits and diseases. However, conventional PRS calculation methods that rely on linear models are limited in their ability to capture complex patterns and interaction effects in high-dimensional genomic data.
View Article and Find Full Text PDFCumulative Dispensing of Oral Corticosteroids Over 12 Months in People with COPD.
Int J Chron Obstruct Pulmon Dis
January 2025
School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Purpose: Oral corticosteroids (OCS) are recommended for the treatment of exacerbations in people with COPD; however, high cumulative lifetime doses (≥1000mg prednisolone-equivalent) are associated with adverse health effects. This issue is well defined in asthma but is less well understood in COPD. The aim of this study was to examine cumulative OCS dispensed to people with COPD over 12 months.
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