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Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges.
Probiotics Antimicrob Proteins
January 2025
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Research into the role of probiotics-often referred to as "living supplements"-in cancer therapy is still in its early stages, and uncertainties regarding their effectiveness remain. Relevantly, chemopreventive and therapeutic effects of probiotics have been determined. There is also substantial evidence supporting their potential in cancer treatment such as immunotherapy.
View Article and Find Full Text PDFA Force-Sensor-Less Approach for Rapid Young's Modulus Identification of Heterogeneous Soft Tissue.
J Biomech Eng
January 2025
State Key Laboratory of Fluid Power and Mechatronic Systems, Department of Mechanical Engineering, Zhejiang University, Hangzhou, 315000, China.
Due to individual differences, accurate identification of tissue elastic parameters is essential for biomechanical modeling in surgical guidance for hepatic venous injections. This paper aims to acquire the absolute Young's modulus of heterogeneous soft tissues during endoscopic surgery with 2D ultrasound images. First, we introduced a force-sensor-less approach that utilizes a pre-calibrated soft patch with a known Young's modulus and its ultrasound images to calculate the external forces exerted by the probe on the tissue.
View Article and Find Full Text PDFBioconversion of mustard oil cake for production of lipase, optimization and direct immobilization from solid-state fermentation extract.
Prep Biochem Biotechnol
January 2025
Department of Physical Science, Sant Baba Bagh Singh University, Jalandhar, Punjab, India.
Fungal lipases are the leading industrial biocatalyst due to their broad applications, but high cost limits their commercial usage. The low-cost agri-residues substrates can reduce the cost of lipase production. However, the compatibility of agri-residue with fungal species, recovery process of lipase and stability of the enzyme are crucial steps.
View Article and Find Full Text PDFGenetic diversity and virulence of group isolates from bloodstream infections.
Microbiol Spectr
January 2025
Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan.
catheter-related bloodstream infections (CRBSIs) are an increasing concern in Japanese hospitals. Although their clinical characteristics have been explored, the genetic relationships and virulence profiles of isolates from CRBSIs remain understudied. Here, using advanced genomic techniques, we investigated the genetic diversity, phylogenetic relationships, and virulence profiles of isolates from patients with bloodstream infections.
View Article and Find Full Text PDFLaboratory evolution of with a natural vitamin B analog reveals roles for cobamide uptake and adenosylation in methionine synthase-dependent growth.
J Bacteriol
January 2025
Department of Plant & Microbial Biology, University of California Berkeley, Berkeley, California, USA.
Bacteria encounter chemically similar nutrients in their environment, which impact their growth in distinct ways. Among such nutrients are cobamides, the structurally diverse family of cofactors related to vitamin B (cobalamin), which function as cofactors for diverse metabolic processes. Given that different environments contain varying abundances of different cobamides, bacteria are likely to encounter cobamides that enable them to grow robustly and also those that do not function efficiently for their metabolism.
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