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Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig.
Anim Microbiome
January 2025
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, 611130, P.R. China.
Background: A. muciniphila (AKK) has attracted extensive research interest as a potential next-generation probiotics, but its role in intestinal pathology is remains unclear. Herein, this study was conducted to investigate the effects of A.
View Article and Find Full Text PDFFecal microbiota transplantation from postmenopausal osteoporosis human donors accelerated bone mass loss in mice.
Front Cell Infect Microbiol
December 2024
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objectives: To investigate the effect of gut microbiota from postmenopausal osteoporosis patients on bone mass in mice.
Methods: Fecal samples were collected from postmenopausal women with normal bone mass (Con, n=5) and postmenopausal women with osteoporosis (Op, n=5). Microbial composition was identified by shallow shotgun sequencing.
Formononetin alleviates ulcerative colitis via reshaping the balance of M1/M2 macrophage polarization in a gut microbiota-dependent manner.
Phytomedicine
December 2024
College of Acupuncture and Tuina, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China; College of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China; Laboratory Animal Science and Technology Center, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China; Key Laboratory of Prevention and Treatment of Immunological and Metabolic Diseases Related to Prescription and Syndrome, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China. Electronic address:
Article Synopsis
- Ulcerative colitis (UC) is a challenging inflammatory bowel disease, and this study explores the effectiveness of the natural compound Formononetin (FN), which has anti-inflammatory and antioxidant properties, against UC.
- The researchers used a mouse model of colitis induced by dextran sulfate sodium (DSS) and treated them with FN to assess its impact on macrophage activity and gut microbiota.
- Results showed that FN reduced inflammation and improved gut microbiota balance, but lost effectiveness after gut flora depletion, indicating that FN's benefits rely on healthy gut microbiota.
Stable pharmaceutical composition of cryo-protected non-pyrogenic isotonic chains of magnetosomes for efficient tumor cell destruction at 45 ± 1 °C under alternating magnetic field or ultrasound application.
Nanoscale
October 2024
Nanobacterie SAS, 36 boulevard Flandrin, 75116, Paris, France.
We report a method to prepare biocompatible, stable, and highly pure iron oxide nano-minerals by following the steps consisting of: (i) amplifying magnetotactic bacteria in non-toxic minimal growth media; (ii) extracting magnetosomes from magnetotactic bacteria under alkaline lysis; (iii) heating magnetosomes above 400 °C to yield sterile magnetosome minerals, M-uncoated, devoid of active non-denatured bacterial organic material; (iv) coating M-uncoated with biocompatible carboxymethyl-dextran (CMD) compounds to yield stable M-CMD; (v) adding 5% sorbitol to M-CMD; and (vi) lyophilizing these mixtures, resulting in formulated nano-minerals in powder forms, designated as (M-CMD). The long-term stability of the final products is demonstrated by re-suspending (M-CMD) in water after 12 months of storage, and by showing that these formulated magnetosomes have preserved their stability in suspension, chain arrangement, carbon content, surface charge, and surface composition. Furthermore, the formulation is optimized to yield an isotonic magnetosome suspension with an osmolality of between 275 and 290 mOsm kg HO upon reconstitution.
View Article and Find Full Text PDFNetwork pharmacology and experimental verification revealing valnemulin alleviates DSS-induced ulcerative colitis by inhibiting intestinal senescence.
Int Immunopharmacol
November 2024
School of Basic Medicine, Dali University, Dali, Yunnan, 671000, China. Electronic address:
Ulcerative colitis (UC) is a chronic inflammatory disease that is increasing in prevalence globally. Senescence is characterized by a specific chronic, low-grade, "sterile" inflammatory state known as inflammaging, suggesting that senescence may exacerbate the severity of UC. However, the link between UC and senescence remains unclear.
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