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Novel D-Ribofuranosyl Tetrazoles: Synthesis, Characterization, In Vitro Antimicrobial Activity, and Computational Studies.
ACS Omega
January 2025
Applied Chemistry and Environment Laboratory, Applied Bioorganic Chemistry Team, Faculty of Science, Ibn Zohr University, Agadir 80000, Morocco.
The goal of this study was to synthesize and evaluate new antimicrobial compounds. We specifically focused on the development of 2,5-disubstituted tetrazole derivatives containing the O-methyl-2,3-O-isopropylidene-(D)-ribofuranoside groups through N-alkylation reactions. The synthesized compounds were characterized using H and C nuclear magnetic resonance (NMR) spectroscopy.
View Article and Find Full Text PDFRisk assessment and photo-disinfection of antibiotic residues and antibiotic-resistant bacteria in water sources from Ede, Nigeria.
Heliyon
January 2025
African Centre of Excellence for Water and Environmental Research (ACEWATER), Redeemer's University, Osun State, Nigeria.
Environmental antibiotic residues (EARs) and antibiotic-resistant bacteria (ARB) are known to contribute to global antimicrobial resistance (AMR). This study investigated EAR levels in selected wells, river, abattoir wastewater, bottled water and sachet water from Ede, Nigeria. Ecological risk quotient (RQ) and health risk (Hazard quotient) of the levels of these EARs, ARB and multidrug-resistant bacteria (MDR) with their antibiotic resistance were calculated.
View Article and Find Full Text PDFEvaluation of an indirect Na1.7 inhibitor as adjunctive analgesic in burn-related neuropathic pain in a cat.
Vet Anaesth Analg
January 2025
Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL, USA.
Burn-related neuropathic pain (BRNP) can arise following burn-induced nerve damage, affects approximately 6% of burned human patients and can result in chronic pain. Although widely studied in humans, data on BRNP or its treatment in animals is lacking. A 4-year-old domestic shorthair cat was presented with an infected, non-healing wound suspected to be a caustic burn.
View Article and Find Full Text PDFHerbicidal and Antibacterial Secondary Metabolites Isolated from the -Derived Endophytic Fungus TE-739D.
Plants (Basel)
January 2025
Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Endophytic fungi possess a unique ability to produce abundant secondary metabolites, which play an active role in the growth and development of host plants. In this study, chemical investigations on the endophytic fungus TE-739D derived from the cultivated tobacco ( L.) afforded two new polyketide derivatives, namely japoniones A () and B (), as well as four previously reported compounds -.
View Article and Find Full Text PDFAssessment of Antibiotic Resistance Among Isolates of spp. and spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
Pathogens
January 2025
MicroART-Antibiotic Resistance Team, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
One of the significant challenges facing modern medicine is the rising rate of antibiotic resistance, which impacts public health, animal health, and environmental preservation. Evaluating antibiotic resistance in wildlife and their environments is crucial, as it offers essential insights into the dynamics of resistance patterns and promotes strategies for monitoring, prevention, and intervention. and genera isolates were recovered from fecal samples of wild animals and environmental samples using media without antibiotic supplementation.
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