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P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.
Theranostics
January 2025
Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland.
Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel that is expressed throughout the brain.
View Article and Find Full Text PDFHow confident are Queensland paramedics with seizure recognition, differentiation, and management? A pilot study.
Australas Emerg Care
January 2025
Department of Paramedicine, Monash University, 47-49 Moorooduc Hwy, Frankston, Victoria 3199, Australia; Department of Paramedics, Jordan University of Science and Technology, Irbid, Jordan; Duke Medical School, National University of Singapore, Singapore.
Background: Paramedics in Australia present as the opportune medical personnel to initiate medical intervention of seizure presentations and perform a fundamental role in the prevention of seizure associated morbidity and mortality. Despite being well equipped to manage seizures, no literature exists regarding their confidence to recognise, differentiate, or manage seizures.
Methods: An online cross-sectional survey was undertaken by 168 paramedics practicing clinically for the Queensland Ambulance Service in Australia.
Rhythmic EEG patterns: The oldest idea in the EEG world, but without an obvious definition.
Clin Neurophysiol
January 2025
Epilepsy and EEG Unit, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
The word "rhythmic" was quickly introduced in the vocabulary of the electroencephalographers with the discovery of the alpha rhythm and typical discharges of spike-and-waves at 3 Hz in childhood absence epilepsy, but without any definition until recently. In its last revision (2017), the International Federation of Clinical Neurophysiology proposed a specific definition. The word "rhythmic" is "applied to regular waves occurring at a constant period and of relatively uniform morphology.
View Article and Find Full Text PDFClinical outcomes of adults with intracranial grade 1 and 2 ganglioglioma.
J Clin Neurosci
January 2025
The Walton Centre NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool L9 7LJ UK; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Ganglioglioma is a rare primary brain tumour that most frequently occurs in children and young adults. They are generally low-grade and have a favourable prognosis, but there is limited literature to guide the optimal management. The aim of this study was to investigate the clinical outcomes of adults with intracranial ganglioglioma, and to determine the frequency and duration of radiological follow-up.
View Article and Find Full Text PDFThis paper is based on a presentation made at the 9th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures in April 2024. Status Epilepticus (SE) is a neurological emergency involving prolonged seizures that disrupt brain function and may cause severe, long-term neurological damage. Developmental and Epileptic Encephalopathies (DEEs), a group of severe genetic disorders with early-onset epilepsy, often exhibit SE episodes that compound their inherent cognitive and developmental challenges.
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