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Apolipoprotein E3 and E4 isoforms exhibit differing effects in countering endotoxins.
J Biol Chem
January 2025
Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden. Electronic address:
Apolipoprotein E (APOE) is distributed across various human tissues and plays a crucial role in lipid metabolism. Recent investigations have uncovered an additional facet of APOE's functionality, revealing its role in host defense against bacterial infections. To assess the antibacterial attributes of APOE3 and APOE4, we conducted antibacterial assays using P.
View Article and Find Full Text PDFExploring diazotrophic diversity: unveiling Nif core distribution and evolutionary patterns in nitrogen-fixing organisms.
BMC Genomics
January 2025
Laboratory of Artificial Intelligence Applied to Bioinformatics, Professional and Technical Education Sector - SEPT, UFPR, Curitiba, Paraná, Brazil.
Background: Diazotrophs carry out biological nitrogen fixation (BNF) using the nitrogenase enzyme complex (NEC), which relies on nitrogenase encoded by nif genes. Horizontal gene transfer (HGT) and gene duplications have created significant diversity among these genes, making it challenging to identify potential diazotrophs. Previous studies have established a minimal set of Nif proteins, known as the Nif core, which includes NifH, NifD, NifK, NifE, NifN, and NifB.
View Article and Find Full Text PDFPreclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency.
Commun Med (Lond)
January 2025
Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, ME, USA.
Background: Multiple Sulfatase Deficiency (MSD) is a rare inherited lysosomal storage disorder characterized by loss of function mutations in the SUMF1 gene that manifests as a severe pediatric neurological disease. There are no available targeted therapies for MSD.
Methods: We engineered a viral vector (AAV9/SUMF1) to deliver working copies of the SUMF1 gene and tested the vector in Sumf1 knock out mice that generally display a median lifespan of 10 days.
An Extended Langevinized Ensemble Kalman Filter for non-Gaussian Dynamic Systems.
Comput Stat
September 2024
Department of Statistics, Purdue University, West Lafayette, IN 47907.
State estimation for large-scale non-Gaussian dynamic systems remains an unresolved issue, given nonscalability of the existing particle filter algorithms. To address this issue, this paper extends the Langevinized ensemble Kalman filter (LEnKF) algorithm to non-Gaussian dynamic systems by introducing a latent Gaussian measurement variable to the dynamic system. The extended LEnKF algorithm can converge to the right filtering distribution as the number of stages become large, while inheriting the scalability of the LEnKF algorithm with respect to the sample size and state dimension.
View Article and Find Full Text PDFRisk Assessment of Cyclaniliprole Resistance in Peach-Potato Aphid Myzus persicae: Laboratory Selection, Inheritance, and Cross-Resistance Patterns.
Arch Insect Biochem Physiol
January 2025
Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.
Cyclaniliprole, a type of the third-generation anthranilic diamide insecticide, was mainly used for management of various pests. Myzus persicae (Hemiptera: Aphididae), known as the peach-potato aphid, is an economically essential pest with worldwide distribution. However, the risk assessment of cyclaniliprole in M.
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