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Metabolomics approach to evaluate diclazuril-induced developmental toxicity in zebrafish embryo.
Aquat Toxicol
January 2025
Analytical Chemistry Laboratory, ASSIST Group, Main campus, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, Lucknow India. Electronic address:
Anticoccidials, commonly used in veterinary medicine to treat coccidiosis in food-producing animals, particularly in poultry farming, are associated with potential environmental risks due to their excretion in manure and subsequent land-spreading. Diclazuril, a widely used anticoccidial, has been detected in groundwater, raising concerns about its impact on non-target species. This study investigates the developmental toxicity of diclazuril in zebrafish embryos over a 96-hour exposure period, utilizing biomarkers such as oxidative stress indicators and metabolomic profiles.
View Article and Find Full Text PDFEfficacy of myrrh extract against Eimeria labbeana-like experimental infection in Columba livia domestica: in vivo study.
BMC Vet Res
December 2024
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Background: The Protozoan pathogen Eimeria is a significant issue in poultry production. Scientists are concerned with finding alternative strategies due to the spread of resistance against the commonly employed coccidiostats. This study examined how well myrrh extract (MyE) protected domesticated pigeons from an experimental Eimeria labbeana-like infection.
View Article and Find Full Text PDFEvaluation of the efficicacy of myrcene in the treatment of Eimeria tenella and Toxoplasma gondii infection.
J Vet Med Sci
January 2025
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China.
Protozoan parasites such as Eimeria tenella and Toxoplasma gondii pose significant health challenges in livestock and humans. The limited treatment options and rising drug resistance underscore the urgent need for new therapies. This study investigates myrcene, a monoterpene hydrocarbon classified for its antiprotozoal potential against E.
View Article and Find Full Text PDFAnticoccidial activities of Piper betle L essential oil on Eimeria tenella oocysts.
Sci Rep
October 2024
Faculty of Veterinary Medical Science, Osaka Metropolitan University, Osaka, Japan.
Article Synopsis
- Coccidiosis is a major problem in the poultry industry, typically managed with synthetic antibiotics and disinfectants.
- This study shows that Piper betle L essential oil (PBEO) can effectively combat Eimeria tenella, demonstrating up to 95.33% anticoccidial activity by disrupting oocyst walls and inhibiting sporulation.
- Key compounds identified in PBEO, such as eugenol, highlight its potential as a natural alternative to conventional treatments, warranting further research into its applications against coccidian parasites.
Extract as a Potential Anticoccidial Agent: Evidence of Its MUC2 Regulatory Impact in Murine Jejunum.
Vet Sci
October 2024
Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11759, Egypt.
is a parasite that causes coccidiosis in a variety of animals, leading to nutritional imbalances, issues with food digestion and absorption, low weight, and intestinal inflammation of varying degrees in its hosts. Anticoccidial medication resistance has become a significant obstacle to disease control efforts, leading to a renewed focus on discovering novel chemicals for alternative therapeutic approaches. The purpose of this study was to determine the efficacy of extract (HpE) in treating eimeriosis in mice.
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