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- A study aimed to assess the long-term outcomes (20-30 years) of patients who underwent surgery for Blount disease by reviewing medical records and contacting former patients.
- Out of 105 eligible patients, only 16 agreed to participate, revealing a high prevalence of obesity (average BMI of 45.8) and some concerning health outcomes, such as knee osteoarthritis.
- The findings suggest that retrospective studies have limitations in evaluating the long-term effects for pediatric orthopedic conditions, highlighting the need for more prospective research focused on obesity and socioeconomic factors in treatment.
The Evalutation of the Effect of 12 Weeks of Water Aerobic Exercise and Atrovastatin Drug on Apolipoproteins A1 Changes, ANP, BNP and CRP in Older Men with Cardiovascular Disesaes.
Clin Ter
July 2022
Sapienza Universiry of Rome, Department of Public Health and Infectious Disease Education Department of Iran, Shiraz.
Background: The aim of this study is to investigate the effect of of 12 weeks of water aerobic exercise and atrovastain drug on apolipoproteins changes A1, ANP, BNP and CRP in older men with cardiovascular disesaes.
Methods: In this study, we chose 40 patients with cardiovascular disease that were divideded in to four groups. Experimental groups selected exercise 3 times per weeks during 3 months with the method ofwalking on the water and carnal swimming.
Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study.
EClinicalMedicine
September 2021
Haemostasis Research Unit, Department of Haematology, UCL, UK.
Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.
Methods: This single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [aβGPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I βGPI (aD1β2GPI) IgG.
Orofacial features and pediatric dentistry in the long-term management of Infantile Pompe Disease children.
Orphanet J Rare Dis
November 2020
Division of Dentistry, Bambino Gesù Children's Research Hospital IRCCS, Rome, Italy.
Background: Glycogen storage disease type II (GSDII) or Pompe disease is a rare autosomal recessive metabolic disorder that leads to intracellular glycogen storage in many tissues, mainly in skeletal muscle, heart and liver. Facial muscle weakness and altered craniofacial growth are very common in Pompe disease children. In this paper we describe the orofacial features in two children affected by GSDII and illustrate a multidisciplinary approach that involved enzyme replace therapy, non-invasive ventilation (NIV) and pediatric dentistry with 5-year follow-up.
View Article and Find Full Text PDFConditional Financing of Drugs in the Netherlands: Past, Present, and Future-Results From Stakeholder Interviews.
Value Health
April 2019
The National Healthcare Institute, Diemen, The Netherlands; Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.
Background: Conditional financing (CF) of hospital drugs was implemented in the Netherlands as a form of managed entry agreements between 2006 and 2012. CF was a 4-year process comprising 3 stages: initial health technology assessment of the drug (T = 0), conduct of outcomes research studies, and reassessment of the drug (T = 4).
Objectives: To analyze stakeholder experiences in implementing CF in practice.
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