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Variable power functional dilution adjustment of spot urine.
Sci Rep
January 2025
Praxis Dr.Carmine, Etzelstrasse 21, Pfaeffikon SZ, 8808, Switzerland.
Spot-urinary biomarkers are crucial in medical, epidemiological, and environmental studies, but their variability due to hydration levels requires precise dilution adjustments. Traditional methods, like conventional creatinine correction (CCRC), are limited in compensating for variations in urine concentration, causing substantial inconsistencies, particularly at the extremes of the diuresis spectrum. While restricting the creatinine (CRN) range to 0.
View Article and Find Full Text PDFVersatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle.
Nat Commun
January 2025
State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, PR China.
Heterotrophic denitrifiers play crucial roles in global carbon and nitrogen cycling. However, their inability to oxidize sulfide renders them vulnerable to this toxic molecule, which inhibits the key enzymatic reaction responsible for reducing nitrous oxide (NO), thereby raising greenhouse gas emissions. Here, we applied microcosm incubations, community-isotope-corrected DNA stable-isotope probing, and metagenomics to characterize a cohort of heterotrophic denitrifiers in estuarine sediments that thrive by coupling sulfur oxidation with denitrification through chemolithoheterotrophic metabolism.
View Article and Find Full Text PDFValidation of an online imitation-inhibition task.
Behav Res Methods
January 2025
Leuphana University Lueneburg, Lueneburg, Germany.
People automatically imitate a wide range of different behaviors. One of the most commonly used measurement methods to assess imitative behavior is the imitation-inhibition task (Brass et al., 2000).
View Article and Find Full Text PDFCancer-associated fibroblasts promote oral squamous cell carcinoma progression by targeting ATP7A via exosome-mediated paracrine miR-148b-3p.
Cell Signal
January 2025
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, 56 Lingyuan Road West, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Cuproptosis is a newly discovered form of non-apoptotic cell death. Cancer-associated fibroblasts (CAFs) can secrete various bioactive substances, including exosomes, to promote tumor progression. However, the impact of CAFs on the regulation of copper metabolism and cuproptosis in oral squamous cell carcinomas (OSCC) has not been investigated.
View Article and Find Full Text PDFUnderstanding the sorption of paraben on plastics using molecular dynamics simulations.
Int J Pharm
January 2025
Drug Product Technologies, Process Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
In a previous publication, we determined the kinetics and equilibrium for the sorption of propylparaben to polyvinyl chloride (PVC). In this work, we extend that study to investigate the sorption of methylparaben and propylparaben on tubing surfaces made of PVC and fluorinated ethylene propylene (FEP) using molecular dynamics simulations. The simulations suggest the mechanism of sorption to be adsorption.
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