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A parallel bioreactor strategy to rapidly determine growth-coupling relationships for bioproduction: a mevalonate case study.
Biotechnol Biofuels Bioprod
January 2025
Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Background: The climate crisis and depleting fossil fuel reserves have led to a drive for 'green' alternatives to the way we manufacture chemicals, and the formation of a bioeconomy that reduces our reliance on petrochemical-based feedstocks. Advances in Synthetic biology have provided the opportunity to engineer micro-organisms to produce compounds from renewable feedstocks, which could play a role in replacing traditional, petrochemical based, manufacturing routes. However, there are few examples of bio-manufactured products achieving commercialisation.
View Article and Find Full Text PDFElectrostatically tuning radical addition and atom abstraction reactions with distonic radical ions.
Chem Sci
January 2025
Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong Wollongong New South Wales 2522 Australia
Although electrostatic catalysis can enhance the kinetics and selectivity of reactions to produce greener synthetic processes, the highly directional nature of electrostatic interactions has limited widespread application. In this study, the influence of oriented electric fields (OEF) on radical addition and atom abstraction reactions are systematically explored with ion-trap mass spectrometry using structurally diverse distonic radical ions that maintain spatially separated charge and radical moieties. When installed on rigid molecular scaffolds, charged functional groups lock the magnitude and orientation of the internal electric field with respect to the radical site, creating an OEF which tunes the reactivity across the set of gas-phase carbon-centred radical reactions.
View Article and Find Full Text PDFAccuracy of flow volume estimation in the dilated aorta using 4D flow MRI: a pulsatile phantom study.
Physiol Meas
January 2025
Electronics, Universidad Favaloro, Solis 453, Buenos Aires, Buenos Aires, 1078, ARGENTINA.
Aortic dilatation is a severe pathology that increases the risk of rupture and its hemodynamics could be accurately assessed by using the 4D flow cardiovascular magnetic resonance (CMR) technique but flow assessment under complex flow patterns require validation. The aim of this work was to develop an in vitro system compatible with CMR to assess the accuracy of volume flow measurements in dilated aortas. Approach.
View Article and Find Full Text PDFCyclopentadienyl cations.
Chem Sci
December 2024
La Trobe University, Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science Melbourne Victoria 3086 Australia
This perspective covers the chemistry of cyclopentadienyl cations from the first synthetic attempts generating transient variants to their successful isolation earlier this year. They are highly reactive species that researchers struggled to isolate and characterize that stifled efforts to explore their reactivity. The recent isolation of a cyclopentadienyl cation enabled characterization and reactivity studies that make this an exciting time in the area that will undoubtedly inspire research in cyclic four π-electron systems.
View Article and Find Full Text PDFA Comparative Review on the Production of Factor VIII in Human and Non-human Hosts.
Curr Pharm Des
January 2025
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Hemophilia A (HA) is an inherited condition that is characterized by a lack of coagulation factor VIII (FVIII), which is needed for blood clotting. To produce recombinant factor VIII (rFVIII) for treatment, innovative methods are required. This study presents a thorough examination of the genetic engineering and biotechnological methods that are essential for the production of this complex process.
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