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Analysis of mA-related lncRNAs for prognostic and immunotherapeutic response in hepatocellular carcinoma.
J Cancer
February 2024
Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.
RNA methylation modifications are important post-translational modifications that are regulated in an epigenetic manner. Recently, N-methyladenosine (mA) RNA modifications have emerged as potential epigenetic markers in tumor biology. Gene expression and clinicopathological data of LIHC were obtained from the cancer genome atlas (TCGA) database.
View Article and Find Full Text PDFNon-coding CGG repeat expansion in is associated with a phenotype of oculopharyngodistal myopathy.
J Med Genet
March 2024
Department of Neurology, Peking University First Hospital, Beijing, China
Background: Oculopharyngodistal myopathy (OPDM) is a rare adult-onset neuromuscular disease, associated with CGG repeat expansions in the 5' untranslated region of , , and . However, the genetic cause of a proportion of pathoclinically confirmed cases remains unknown.
Methods: A total of 26 OPDM patients with unknown genetic cause(s) from 4 tertiary referral hospitals were included in this study.
Pathoclinical associations between panic disorders and the brain-derived neurotrophic factor Val66Met polymorphism: an updated meta-analysis.
Psychiatr Genet
April 2023
Department of Psychiatry, Shenyang Mental Health Center, Shenyang.
Prior studies have indicated the pathological role of brain-derived neurotrophic factor (BDNF) gene polymorphism in panic disorders (PD). A functionally less active BDNF Val66Met mutant was previously detected in PD patients with different ethnic backgrounds. However, the results remain inconclusive or inconsistent.
View Article and Find Full Text PDFLimy Bile Syndrome: A Report of a Rare Case.
Cureus
July 2022
Surgery, Seven Star Hospital, Nagpur, IND.
Milk of Calcium Bile or Limy Bile Syndrome (LBS) is a sporadic and infrequent complication of cholecystitis in which the gallbladder is filled with radio-opaque, abnormal bile secretion. A 40-year-old female came to a tertiary care hospital with symptoms of recurrent pain upper abdomen for two years. On examination, the patient had mild jaundice and mild tenderness at Murphy's point exacerbated on deep inspiration.
View Article and Find Full Text PDFMeaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease.
Alzheimers Res Ther
April 2022
Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV, USA.
Background: The need for preventive therapies that interrupt the progression of Alzheimer's disease (AD) before the onset of symptoms or when symptoms are emerging is urgent and has spurred the ongoing development of disease-modifying therapies (DMTs) in preclinical and early AD (mild cognitive impairment [MCI] to mild dementia). Assessing the meaningfulness of what are likely small initial treatment effects in these earlier stages of the AD patho-clinical disease continuum is a major challenge and warrants further consideration. BODY: To accommodate a shift towards earlier intervention in AD, we propose meaningful benefits as a new umbrella concept that encapsulates the spectrum of potentially desirable outcomes that may be demonstrated in clinical trials and other studies across the AD continuum, with an emphasis on preclinical AD and early AD (i.
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