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Therapeutic challenge: a giant, infiltrating intrathyroidal thymic carcinoma of the thyroid gland.
Pol Arch Intern Med
June 2023
Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk, Gdańsk, Poland.
Intrasalivary Thymic Carcinoma: A Case Report and Literature Review.
Head Neck Pathol
September 2022
Department of Pathomorphology, Medical University of Gdansk, Smoluchowskiego 17, Gdańsk, Poland.
Ectopic thymic carcinomas are rarely diagnosed in the thyroid gland, let alone in extrathyroid tissues. In the currently available literature, only five cases of extrathyroidal malignancies with thymic differentiation have been reported as arising in the major salivary glands. A 69-year-old female presented with a slow-growing palpable mass in the left parotid gland.
View Article and Find Full Text PDFMalignant thymoma - the most common neoplasm in goats.
Pol J Vet Sci
September 2019
Division of Infectious Diseases, Department of Small Animal Diseases with Clinic, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland.
In the literature the occurrence of thymomas in goats varies from 0.7 to 25%, depending on the study. Therefore the current investigation was carried out to determine the prevalence of thymoma in goats in Poland.
View Article and Find Full Text PDFComprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma.
Oncotarget
April 2017
Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.
Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in several types of malignant tumors sometimes in association with increased tumor aggressiveness and poor clinical outcome. In the present study, 1562 tumors were immunohistochemically analyzed for mesothelin expression using two different types of mouse monoclonal antibodies (5B2 and MN-1) to determine the clinical usefulness of mesothelin immunohistochemistry as well as to pinpoint potential targets for future anti-mesothelin therapy. Also, characterization of selected mesothelin-positive tumors was performed by immunohistochemistry and oncogene sequencing.
View Article and Find Full Text PDFTumor heterogeneity at protein level as an independent prognostic factor in endometrial cancer.
Transl Oncol
October 2014
Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-211 Gdańsk, Poland. Electronic address:
Intratumor heterogeneity implies heterogeneous protein function, facilitating tumor adaptation which results in therapeutic failure. We hypothesized that tumor heterogeneity at protein level may influence the course of the disease. As a single biopsy might not represent the full biologic complexity of the tumor, we have analyzed immunohistochemically four different cores obtained from each primary tumor within the cohort of 364 patients with endometrial cancer (EC).
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