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Modulation of oxidative stress/NMDA/nitric oxide pathway by topiramate attenuates morphine dependence in mice.
Heliyon
December 2024
Department of Biomedical Sciences, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Khyber Pakhtunkhwa, Pakistan.
Morphine belongs to the class of opioids and is known for its potential to cause dependence and addiction, particularly with prolonged use. Due to the associated risks, caution must be taken when prescribing and limiting its clinical use. Overexpression of N-methyl-D-aspartate (NMDA) receptors, nitric oxide and cGMP pathway has been implicated in exacerbate the development of morphine dependence and withdrawal.
View Article and Find Full Text PDFFormation of chronic morphine withdrawal memories requires C1QL3-mediated regulation of PSD95 in the mouse basolateral amygdala.
Biochem Biophys Res Commun
August 2024
MOE Frontiers Center for Brain Science, School of Basic Medical Sciences, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- - This study investigates how the basolateral amygdala (BLA) and a protein called C1QL3 contribute to forming memories related to chronic morphine withdrawal using methods like conditioned place aversion (CPA).
- - The research finds that inhibiting the BLA during withdrawal reduces CPA scores, highlighting its critical role in withdrawal memory, while changes in C1QL3 expression in the BLA are also linked to this memory formation.
- - Additionally, downregulating C1QL3 expression in the BLA disrupts withdrawal memory formation, and the study identifies PSD95 as a critical downstream factor influenced by C1QL3.
Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation.
Neurochem Res
February 2024
Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Morphine (MPH) is widely used for pain management; however, long-term MPH therapy results in antinociceptive tolerance and physical dependence, limiting its clinical use. Zingerone (ZIN) is a natural phenolic compound with neuroprotective effects. We investigated the effects of single and repeated doses of ZIN on MPH-induced tolerance, dependence, and underlying biochemical mechanisms.
View Article and Find Full Text PDFNucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.
J Clin Invest
September 2023
College of Forensic Science, Key Laboratory of National Health Commission for Forensic Science, National Biosafety Evidence Foundation, Xi'an Jiaotong University, Xi'an, China.
The nucleus accumbens (NAc) is the most promising target for drug use disorder treatment. Deep brain stimulation (DBS) of NAc is effective for drug use disorder treatment. However, the mechanisms by which DBS produces its therapeutic effects remain enigmatic.
View Article and Find Full Text PDFEffect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence.
Transl Psychiatry
November 2022
Center for Regenerative Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in Wistar rats which shows classic signs of morphine intoxication and a severe naloxone-induced withdrawal syndrome. A single intranasal-systemic administration of MSCs secretome fully inhibited (>95%; p < 0.
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