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Enhancing HER2 testing in breast cancer: predicting fluorescence in situ hybridization (FISH) scores from immunohistochemistry images via deep learning.
J Pathol Clin Res
March 2025
Division of Computational Pathology and AI, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Breast cancer affects millions globally, necessitating precise biomarker testing for effective treatment. HER2 testing is crucial for guiding therapy, particularly with novel antibody-drug conjugates (ADCs) like trastuzumab deruxtecan, which shows promise for breast cancers with low HER2 expression. Current HER2 testing methods, including immunohistochemistry (IHC) and in situ hybridization (ISH), have limitations.
View Article and Find Full Text PDFResponses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta.
Sci Rep
March 2025
Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minamiku, Hiroshima, Hiroshima, 734-8553, Japan.
The circulatory system receives ionizing radiation at various dose rates. Given mounting epidemiological evidence of elevated radiation risks for diseases of the circulatory system (DCS), the International Commission on Radiological Protection recently recommended the first ever dose threshold for DCS. However, very little knowledge exists about whether radiation effects differ with dose rates and among tissues of the circulatory system.
View Article and Find Full Text PDFWe detected neutralizing antibodies, viral RNA, and sialic acid receptors for Alphainfluenzavirus influenzae in urban coatis (Nasua nasua) in Brazil, suggesting exposure and susceptibility. We used hemagglutination inhibition, reverse transcription quantitative PCR, and histochemistry for detection. Increased epidemiologic wildlife surveillance would improve influenza A emergency event response.
View Article and Find Full Text PDFBackground and objectives Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by chronic immune complex deposition and involvement of multiple organ systems. Among individuals with SLE, a greater percentage are at a higher risk of developing lupus nephritis (LN). Renal biopsies play a pivotal role in diagnosing, managing, and predicting the prognosis of LN.
View Article and Find Full Text PDFReal-time PCR and immunohistochemistry detection of Wolbachia in adult Dirofilaria immitis from dogs treated with doxycycline and ivermectin.
Parasit Vectors
February 2025
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Background: Wolbachia is present in all life stages of Dirofilaria immitis. Wolbachia surface protein (WSP) can be highly immunogenic and induce acute inflammatory reactions in the host upon worm death. To avoid the abrupt release of Wolbachia and its antigens from deceased parasites, the American Heartworm Society (AHS) has recommended using doxycycline (DOXY) and having a 1-month wait period between the DOXY treatment and the adulticidal process for Wolbachia elimination.
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