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Investigating the Relative Importance of Tear Homeostatic Signs for the Diagnosis of Dry Eye Disease.
Ocul Surf
January 2025
Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand; College of Health & Life Sciences, School of Optometry, Aston University, Birmingham, UK.
Aim: Disease misdiagnosis is more likely if standardised diagnostic criteria are not used. This study systematically examined the effect on diagnosing dry eye disease (DED), when tests for evaluating tear film homeostasis were included/excluded from a multi-test protocol.
Method: For 1427 participants across five sites, data for the full suite of diagnostic tests defined in the Tear Film and Ocular Surface Society Dry Eye Workshop II (TFOS DEWS II) Diagnostic Methodology report algorithm were evaluated; diagnostic sensitivity was calculated when individual signs were removed, and when different combinations of signs were required.
Diagnostic Accuracy of a Point-Of-Care aMMP-8 Test for Discriminating Periodontal Health Status in Adults: Validation Trials and Updated Meta-Analysis.
J Clin Periodontol
January 2025
Perio-Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research and Department of Oral and Maxillofacial Implantology and National Clinical Research Center of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Aim: To evaluate the diagnostic accuracy of an active matrix metalloproteinase-8 (aMMP-8) point-of-care oral rinse test (POC-ORT) for predicting periodontitis in treatment-naïve subjects in two independent studies and update a recent meta-analysis.
Methods: The aMMP-8 POC-ORT index test was performed in a representative population in Hong Kong, China, and a consecutive convenience sample in Shanghai, China. The reference standard was the 2017 World Workshop classification of periodontal diseases.
A novel colorectal cancer test combining microsatellite instability and analysis: Clinical validation and impact on Lynch syndrome screening.
BJC Rep
July 2024
Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Background: Lynch syndrome (LS) is under-diagnosed. UK National Institute for Health and Care Excellence guidelines recommend multistep molecular testing of all colorectal cancers (CRCs) to screen for LS. However, the complexity of the pathway has resulted in limited improvement in diagnosis.
View Article and Find Full Text PDFLevel of Agreement With a Multi-Test Approach to the Diagnosis of Diabetic Foot Osteomyelitis: Methodological Issue.
J Foot Ankle Surg
April 2024
Faculty of medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
Human papillomavirus testing using HPV APTIMA® assay and an external cellularity control in self-collected samples.
J Med Virol
December 2023
Department of Virology, Toulouse University Hospital, Toulouse, France.
In cervical cancer screening programs, the detection of high-risk human papillomavirus (HR-HPV) is now widely implemented on physician-collected samples and has expanded to include self-collected samples. The use of a cellularity control (CC) is needed to reduce false-negative HPV results. An external mRNA CC for the HPV APTIMA® assay was assessed for its analytical performance and the results were compared with both cervix cytobrush samples taken by physicians and self-collected vaginal samples from 148 women.
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