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Evolocumab for early reduction of LDL-C levels in patients with acute ischemic stroke: a randomized controlled trial.
Front Neurol
December 2024
Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background: Low-density lipoprotein cholesterol (LDL-C) has been determined as an established risk factor for acute ischemic stroke (AIS). Despite the recommendation for in-hospital initiation of high-intensity statin therapy in AIS patients, achieving the desired target LDL-C levels remains challenging. Evolocumab, a highly effective and quickly acting agent for reducing LDL-C levels, has yet to undergo extensively exploration in the acute phase of AIS.
View Article and Find Full Text PDFFunctional Expression and Construction of a Self-Sufficient Cytochrome P450 Chimera for Efficient Steroidal C14α Hydroxylation in Escherichia coli.
Biotechnol Bioeng
December 2024
National and Local Joint Engineering Research Center for Biomanufacturing of Choral Chemicals, Zhejiang University of Technology, Hangzhou, People's Republic of China.
C14-functionalized steroids enabled diverse biological activities in anti-gonadotropin and anticancer therapy. However, access to C14-functionalized steroids was impeded by the deficiency of chemical synthetic methods. Recently, several membrane-bound fungal cytochrome P450s (CYPs) have been identified with steroid C14α-hydroxylation activity.
View Article and Find Full Text PDFImmunological Responses, Expression of Immune-Related Genes, and Disease Resistance of Rainbow Trout () Fed Diets Supplied with Capsicum () Oleoresin.
Animals (Basel)
November 2024
Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt.
A 45-day feeding study was carried out to assess the immune-stimulatory effects of capsicum oleoresin when added to rainbow trout diets. A total of 450 fish (mean weight: 155.20 ± 1.
View Article and Find Full Text PDFChlorination of quorum sensing molecules: Kinetics and transformation pathways.
Chemosphere
December 2024
Bundesanstalt für Gewässerkunde, Am Mainzer Tor 1, 56068, Koblenz, Germany; Universität Koblenz, Universitätsstraße 1, 56070, Koblenz, Germany. Electronic address:
The impact of chlorination on quorum sensing molecules (QSMs) is not often addressed in disinfection research. Yet pathogenicity and biofilm formation are controlled by quorum sensing (QS) in many bacteria. Chemical transformation of the compounds could have an impact on all of these processes.
View Article and Find Full Text PDFEffects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet.
J Anim Sci Biotechnol
December 2024
Laboratory of Developmental Nutrition, Department of Animal Science, North Carolina State University, Raleigh, NC, 27695, USA.
Background: Energy deficiency is a leading cause of the high pre-weaning mortality of neonatal piglets in the swine industry. Thus, optimal energy metabolism is of crucial importance for improving the survivability of neonatal piglets. The effective utilization of milk fat as primary energy is indispensably required.
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