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Discovery of Flavonol derivatives as porcine reproductive and respiratory syndrome virus inhibitors.
Bioorg Med Chem Lett
March 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, School of life sciences, Hubei University, Wuhan, Hubei, PR China; Hubei Jiangxia Laboratory, Wuhan, Hubei, PR China. Electronic address:
Porcine reproductive and respiratory syndrome virus (PRRSV) causes serious threat to the global pig industry, and there was still no efficient treatment for porcine reproductive and respiratory syndrome (PRRS). Flavonol compounds were reported to show antiviral activity against a series of different virus. In this study, we designed a series of flavonol derivatives as promising lead structure for PRRSV inhibitors.
View Article and Find Full Text PDFImpaired mitochondrial degradation of CHCHD2 promotes metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma by upregulating VEGFA.
Oncogene
March 2025
Department of Physiology and Pathophysiology, the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Metabolic dysfunction-associated steatohepatitis (MASH) is the fastest-growing cause of liver cancer. The liver microenvironment of patients with MASH supports the development of hepatocellular carcinoma (HCC). Coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2), which is located in both the mitochondria and nucleus, is increased in MASH liver.
View Article and Find Full Text PDFSENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De-SUMOylation of CTH.
Adv Sci (Weinh)
February 2025
Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Abdominal aortic aneurysm (AAA) is a high-risk inflammatory disorder. SENP3, a SUMO2/3-specific protease, is closely involved in the development of cancer. In this study, the aim is to explore the role of SENP3 in macrophages in AAA.
View Article and Find Full Text PDFMechanism of lncRNA ZFAS1 mediating nucleus pulposus cell pyroptosis in intervertebral disc degeneration.
J Orthop Surg Res
February 2025
Department of Minimally Invasive Spine Surgery, Bengbu First People's Hospital, Bengbu, 233000, China.
Article Synopsis
- The study explores how lncRNA ZFAS1 contributes to a type of cell death called pyroptosis in intervertebral disc degeneration caused by TNF-α.
- Silencing ZFAS1 reduces pyroptosis in these nucleus pulposus cells (NPCs) by altering the interaction between miR-155-3p and METTL14, which are key players in this process.
- The findings suggest that targeting the ZFAS1/miR-155-3p/METTL14 pathway could have potential therapeutic implications for treating intervertebral disc degeneration.
OTUD7B is a new deubiquitinase targeting p53.
Theranostics
February 2025
Translational Research Institute, People's Hospital of Zhengzhou University, 450003 Zhengzhou, Henan, China.
The tumor suppressor p53 safeguards against cellular transformation, with its expression regulated by diverse post-translational modifications (PTMs). While polyubiquitination by Mdm2 principally drives its proteasomal degradation, the identity of p53 deubiquitinases (DUBs) remains less well defined. This study investigates the role of the deubiquitinase enzyme OTUD7B in hepatocellular carcinoma (HCC), where it is notably downregulated and proposed to function as a tumor suppressor.
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