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Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer's Disease.
Pharmaceuticals (Basel)
December 2024
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Late-onset Alzheimer's disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative disease that associates with aging and is highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for the use of sodium thiosulfate (STS) as a possible multi-targeting treatment option for LOAD. Sulfur is widely available in our environment and is responsible for forming organosulfur compounds that are known to be associated with a wide range of biological activities in the brain.
View Article and Find Full Text PDFCan Clinical, Psychophysical or Psychological Variables Help in Discriminating Women with Migraines from a Tertiary Center? A Diagnostic Accuracy Study.
Diagnostics (Basel)
December 2024
Department Physical Therapy, Occupational Therapy, Rehabilitation, and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.
Migraine diagnosis is mainly clinically based on symptomatology. The objectives of this study were (1) to determine the ability of pain thresholds to differentiate between women with and without migraines and (2) to determine the ability of clinical, psychological and psychophysical variables to differentiate between women with episodic and chronic migraines. A diagnostic accuracy study was conducted.
View Article and Find Full Text PDFSuccessful management of interdural spinal cysts presenting as radiculopathy caused by epidural venous enlargement: illustrative case.
J Neurosurg Case Lessons
January 2025
Division of Neurosurgery, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Background: The authors report the first case of thoracic interdural spinal cysts presenting as radiculopathy attributed to overdrainage-related cervical venous plexus enlargement. This case emphasizes the importance of considering interdural spinal cysts and cerebrospinal fluid overdrainage in the differential diagnosis of radiculopathy.
Observations: A 37-year-old male patient with a history of orthostatic headache presented with bilateral deltoid muscle atrophy consistent with C5 radiculopathy.
Influence of Obesity, Race and Gender on Radiation Exposure for Epidural Procedures.
Curr Pain Headache Rep
January 2025
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Purpose Of Review: This retrospective, case controlled, comparative evaluation review of radiation exposure during epidural procedures in interventional pain management assessed variations in radiation exposure based on obesity, race, and gender.
Recent Findings: Numerous publications have shown increasing radiation exposure based on body mass index (BMI). However, the influence of race and gender have not been studied.
Life after benign paroxysmal positional vertigo: one-year analysis of recurrence, headaches, neck pain, falls, and functional vestibular symptoms.
Eur Arch Otorhinolaryngol
January 2025
Hospital QuironSalud Infanta Luisa, Seville, Spain.
Article Synopsis
- Benign paroxysmal positional vertigo (BPPV) causes recurring episodes of vertigo, and despite initial symptom resolution, many patients experience relapses and other complications such as migraines, neck pain, and falls after discharge.
- This study observed 124 patients with BPPV and found that 70.97% of them reported new symptoms post-treatment, with prior neck pain, headaches, and migraines being significant predictors for future issues.
- Key findings highlight that low vitamin D levels may increase recurrence risk, and the relationship between anxiety and persistent postural-perceptual dizziness (PPPD) suggests that BPPV is often accompanied by lingering symptoms despite the absence of nystagmus.
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