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Enhancement of neurogenesis and antidepressant-like efficacy through combined activation of Sigma-1 and 5-HT1A receptors: focus on Sigma-1-5-HT1A heteroreceptor complex.
Neurochem Int
January 2025
Beijing Institute of Basic Medical Sciences, 100850, Beijing, People's Republic of China; Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, 100850, Beijing, People's Republic of China. Electronic address:
The sigma-1 receptor (S1R) attracts significant interests as a potential target for rapid-onset antidepressant-like effects, particularly due to its capacity to swiftly stimulate serotonergic neurons in the dorsal raphe nucleus (DRN). However, the precise regulatory mechanism involved remains unclear. Therefore, this study aims to examine the interaction between the selective S1R agonist, SA-4503 and 8-OH-DPAT, a serotonin1A (5-HT1A) receptor agonist, in mice with depressive-like behavior induced by chronic restraint stress (CRS).
View Article and Find Full Text PDFNanoparticle-based Drug Delivery Systems to Modulate Tumor Immune Response for Glioblastoma Treatment.
Acta Biomater
January 2025
School of Materials and Energy, Southwest University, Chongqing 400715, China; Yibin Academy of Southwest University, Yibin 644005, China. Electronic address:
Glioblastoma (GBM) is a primary central nervous system neoplasm, characterized by a grim prognosis and low survival rates. This unfavorable therapeutic outcome is partially attributed to the inadequate immune infiltration and an immunosuppressive microenvironment, which compromises the effectiveness of conventional radiotherapy and chemotherapy. To this end, precise modulation of cellular dynamics in the immune system has emerged as a promising approach for therapeutic intervention.
View Article and Find Full Text PDFHorses of different ages may have to be killed on-farm for purposes other than slaughter (where slaughter is defined as killing for human consumption) either individually (i.e. on-farm killing of unproductive, injured or terminally ill animals) or on a large-scale (i.
View Article and Find Full Text PDFSimulated microgravity predisposes kidney to injury through promoting intrarenal artery remodeling.
FASEB J
January 2025
Department of Nephrology, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, National Clinical Research Center for Kidney Diseases, Nephrology Institute of the Chinese People's Liberation Army, Chinese PLA General Hospital, Beijing, China.
Spaceflight-induced multi-organ dysfunction affects the health of astronauts and the safety of in-orbit flight. However, the effect of microgravity on the kidney and the underlying mechanisms are unknown. In the current study, we used a hindlimb unweighting (HU) animal model to simulate microgravity and employed histological analysis, ischemia-reperfusion experiments, renal ultrasonography, bioinformatics analysis, isometric force measurement, and other molecular experimental settings to evaluate the effects of microgravity on the kidneys and the underlying mechanisms involved in this transition.
View Article and Find Full Text PDFPromoting human rights-based deinstitutionalization in Lithuania by applying the World Health Organization's QualityRights Assessments.
Int J Qual Health Care
January 2025
NGO Mental Health Initiative, Lithuanian Tobacco and Alcohol Control Coalition, Stiklių g. 8, Vilnius LT-01131, Lithuania.
Lithuania ratified the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) in 2010 and started deinstitutionalization in 2014. This reform covers segregated social care institutions where persons with mental health conditions, psychosocial, and/or intellectual disabilities live. It aims to move away from institutional care and towards community-based services.
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