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Cutting through the noise: A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use.
J Prev Alzheimers Dis
January 2025
Clinical Memory Research Unit, Clinical Sciences in Malmö, Lund University, Lund, Sweden; Memory Clinic, Skåne University Hospital, Sweden. Electronic address:
As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinical use. Given the rapid pace of advancements in the field and the wide array of available biomarkers and tests, this review aims to summarize these considerations, evaluate available platforms, and discuss the steps needed to bring plasma biomarker testing to the clinic.
View Article and Find Full Text PDF"Are you ready?" A longitudinal interpretative phenomenological analysis of couples' experiences with breast reconstruction decision-making.
Eur J Oncol Nurs
January 2025
Univ. Lille, CNRS, UMR 9193, SCALab - Sciences Cognitives et Sciences Affectives, F 59000, Lille, France; Laboratoire de psychopathologie et processus de santé, Université Paris Cité, F-92100 Boulogne-Billancourt, France. Electronic address:
Purpose: In this study, we aimed to explore women's and their male partners' experiences with breast reconstruction (BR) decision and to study the evolution of their experiences since undergoing mastectomy to one year after.
Methods: Unstructured individual interviews with four couples facing mastectomy for breast cancer and BR decision-making were conducted following mastectomy (T1) and one year after mastectomy (T2). Longitudinal interpretative phenomenological analysis (LIPA) was conducted on the data.
From Theory to Practice: Viewpoint on Economic Indicators for Trust in Digital Health.
J Med Internet Res
January 2025
Department of Health Services Research Management, AI and Digital Health Lab (Centre for Healthcare Innovation Research), City St George's University, London, United Kingdom.
User trust is pivotal for the adoption of digital health systems interventions (DHI). In response, numerous trust-building guidelines have recently emerged targeting DHIs such as artificial intelligence. The common aim of these guidelines aimed at private sector actors and government policy makers is to build trustworthy DHI.
View Article and Find Full Text PDFPros and Cons of Human Brain Organoids to Study Alzheimer's Disease.
Aging Dis
January 2025
Achucarro Basque Center for Neuroscience, University of the Basque Country, CIBERNED and Biobizkaia, 48940-Leioa, Spain.
There is increasing pressure for researchers to reduce their reliance on animals, particularly in early-stage research. The main reason for that change arises from the different biological behavior of humans that leads to frequent failure of translating data from bench to bed. The advent of organoid technology ten years ago, along with the feasibility of obtaining brain organoids in most laboratories, has created considerable expectations not exempting frustration.
View Article and Find Full Text PDFIs "Rough Sex" Thing? A Survey of Meaning.
J Sex Res
January 2025
School of Psychology, University of Auckland | Waipapa Taumata Rau, Auckland, New Zealand.
The term "rough sex" is widely used, but it is not always clear what it means. Through exploring people's working definitions of "rough sex," we asked what they revealed about the underlying phenomenon it is applied to, and whether it is actually thing. Our online survey of 567 New Zealand respondents (73.
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