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Article Synopsis
  • Child development assessment tests are crucial for educational placement and identifying cognitive weaknesses, but most research has been limited to high-income countries, making adaptation to other contexts challenging.
  • As part of a study on the impact of childhood vaccines in rural Haryana, India, researchers aimed to assess the feasibility of enrolling local children and conducting development assessments for kids aged 18 months to 8 years.
  • A rigorous seven-step adaptation process was developed to culturally and contextually tailor three assessment tests, which included translation, back-translation, iterative adaptation, and field-testing to ensure validity and relevance in the rural setting.
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Objective: To evaluate the association between a short-period, high-dose in utero aspirin exposure and child neurocognitive development.

Design: A propensity score-matched analysis of a multicentre prospective cohort study.

Setting: The US Collaborative Perinatal Project (1959-1976).

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Gestational age at term delivery and children's neurocognitive development.

Int J Epidemiol

January 2022

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Background: Preterm birth is associated with lower neurocognitive performance. However, whether children's neurodevelopment improves with longer gestations within the full-term range (37-41 weeks) is unclear. Given the high rate of obstetric intervention in the USA, it is critical to determine whether long-term outcomes differ for children delivered at each week of term.

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Evaluating working memory outcome measures for children with Down syndrome.

J Intellect Disabil Res

January 2022

Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: There is a critical need for the psychometric evaluation of outcome measures to be used in clinical trials targeting cognition in Down syndrome (DS). This study examines a specific cognitive skill that is of particular importance in DS, working memory, and the psychometric properties of a set of standardised measurements to assess working memory in individuals with DS.

Methods: Ninety children and adolescents ages 6 to 18 years old with DS were assessed on a selection of verbal and visuospatial working memory subtests of standardised clinical assessments at two time points to examine feasibility, distributional qualities, test-retest reliability and convergent validity against a priori criteria.

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Prader-Willi syndrome (PWS) is a genomic imprinting disorder characterized by infantile hypotonia with a poor suck and failure to thrive, hypogenitalism/hypogonadism, behavior and cognitive problems, hormone deficiencies, hyperphagia, and obesity. The Stanford Binet and Wechsler (WAIS-R; WISC-III) intelligence (IQ) tests were administered on 103 individuals with PWS from two separate cohorts [University of California, Irvine (UCI) (N = 56) and Vanderbilt University (N = 47)] and clinical information obtained including growth hormone (GH) treatment, PWS molecular classes, weight and height. Significantly higher IQ scores (p < .

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