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Characterization and Otoprotective Effects of Polysaccharides from .
Molecules
January 2025
Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy.
Hearing loss is one of the most common sensory disorders in humans, and a large number of cases are due to ear cell damage caused by ototoxic drugs including anticancer agents, such as cisplatin. The recent literature reported that hearing loss is promoted by an excessive generation of reactive oxygen species (ROS) in cochlea cells, which causes oxidative stress. Recently, polysaccharides from the cyanobacterium showed many biological activities, including antioxidant activity, suggesting their potential use to combat hearing loss.
View Article and Find Full Text PDFSynthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against Species.
Biomolecules
January 2025
Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Area di Ricerca Site and Headquarters, Via Pietro Castellino 111, 80131 Naples, Italy.
In recent years, fungal infections have emerged as a significant health concern across veterinary species, especially in livestock such as cattle, where fungal diseases can result in considerable economic losses, as well as in humans. In particular, species, notably and , are opportunistic pathogens that pose a threat to both animals and humans. This study focuses on the synthesis and antifungal evaluation of novel 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1,2,4-triazolyl-α-amino acids and their dipeptides, designed to combat fungal pathogens.
View Article and Find Full Text PDFGate- and flux-tunable sin(2φ) Josephson element with planar-Ge junctions.
Nat Commun
January 2025
Univ. Grenoble Alpes, CEA, Grenoble INP, IRIG-PHELIQS, 38000, Grenoble, France.
Hybrid superconductor-semiconductor Josephson field-effect transistors (JoFETs) function as Josephson junctions with gate-tunable critical current. Additionally, they can feature a non-sinusoidal current-phase relation (CPR) containing multiple harmonics of the superconducting phase difference, a so-far underutilized property. Here we exploit this multi-harmonicity to create a Josephson circuit element with an almost perfectly π-periodic CPR, indicative of a largely dominant charge-4e supercurrent transport.
View Article and Find Full Text PDFSpatio-temporal prediction of groundwater vulnerability based on CNN-LSTM model with self-attention mechanism: A case study in Hetao Plain, northern China.
J Environ Sci (China)
July 2025
School of Environmental Studies, China University of Geosciences, Wuhan 430074, China; State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution, China University of Geosciences, Wuhan 430078, China. Electronic address:
Located in northern China, the Hetao Plain is an important agro-economic zone and population centre. The deterioration of local groundwater quality has had a serious impact on human health and economic development. Nowadays, the groundwater vulnerability assessment (GVA) has become an essential task to identify the current status and development trend of groundwater quality.
View Article and Find Full Text PDF[Efficient synthesis of polydatin by a two-enzyme coupled with one-pot method].
Sheng Wu Gong Cheng Xue Bao
January 2025
School of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, Anhui, China.
Traditional Chinese medicine of has been utilized in China for thousands of years. Its primary active compound, polydatin, exhibits a variety of pharmacological effects including the regulation of glucose and lipid metabolism, suppression of cough and asthma, as well as antibacterial and anti-inflammatory properties. However, conventional methods for polydatin production are inadequate to satisfy the market demand.
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