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Periapical bone edema volume in 3D MRI is positively correlated with bone architecture changes.
Insights Imaging
January 2025
Diagnostic and Interventional Radiology, University Hospital of Zurich, University Zurich, Zurich, Switzerland.
Objectives: To compare and correlate bone edema volume detected by 3D-short-tau-inversion-recovery (STIR) sequence to osseous decay detected by a T1-based sequence and conventional panoramic radiography (OPT).
Materials And Methods: Patients with clinical evidence of apical periodontitis were included retrospectively and received OPT as well as MRI of the viscerocranium including a 3D-STIR and a 3D-T1 gradient echo sequence. Bone edema was visualized using the 3D-STIR sequence and periapical hard tissue changes were evaluated using the 3D-T1 sequence.
Clear cell variant of calcifying epithelial odontogenic tumour (Pindborg tumour) of the mandible.
BMJ Case Rep
January 2025
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry, India.
A calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic tumour of epithelial origin accounting for approximately 1% of all odontogenic tumours. The intraosseous form occurs more commonly in the posterior mandible whereas the extraosseous form is common in the anterior maxilla. CEOT is often asymptomatic and presents with a painless swelling of the mandible.
View Article and Find Full Text PDFInvestigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML.
Front Oncol
January 2025
BIOCEV, First Faculty of Medicine, Charles University, Prague, Czechia.
Introduction: Progressing myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) is an indication for hypomethylating therapy (HMA, 5-Azacytidine (AZA)) and a BCL2 inhibitor (Venetoclax, VEN) for intensive chemotherapy ineligible patients. Mouse models that engraft primary AML samples may further advance VEN + AZA resistance research.
Methods: We generated a set of transplantable murine PDX models from MDS/AML patients who developed resistance to VEN + AZA and compared the differences in hematopoiesis of the PDX models with primary bone marrow samples at the genetic level.
Intraosseous basivertebral nerve ablation: A 5-year pooled analysis from three prospective clinical trials.
Interv Pain Med
December 2024
Department of Orthopaedic Surgery, William Beaumont University Hospital, 3811 West 13 Mile Rd, Royal Oak, MI, USA.
Article Synopsis
- Vertebrogenic pain, often linked to damage in vertebral endplates, is transmitted through the basivertebral nerve (BVN) and is associated with Modic changes visible on MRI.
- A five-year follow-up of three clinical trials assessing intraosseous radiofrequency ablation (BVNA) shows significant pain and functional improvement in patients with chronic low back pain.
- Out of 320 participants, 249 (78%) completed the study, revealing major reductions in pain scores and enhancements in disability index, demonstrating BVNA as an effective treatment option.
Self-Directed Skills Laboratories Increase Emergency Medicine Physician Confidence in High-Acuity, Low-Opportunity Procedures.
Mil Med
December 2024
Department of Emergency Medicine, Naval Medical Center Portsmouth, Portsmouth, VA 23708, USA.
Introduction: The critical role of emergency physicians in military settings underscores the necessity for a broad and proficient skill set, especially in life-saving procedures such as thoracostomies, endotracheal intubations, and cricothyrotomies, to maintain combat readiness. The current peacetime phase, however, presents challenges in maintaining these skills because of decreased exposure to high-acuity medical scenarios. This decrease in exposure jeopardizes skills retention among military emergency medicine physicians, highlighted by studies showing a significant decline in performance over time because of reduced practice.
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