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Gout management using uricase and sodium citrate hollow mesoporous nanomotors.
Nat Commun
March 2025
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Uricase (UOx)-based gout treatments are generally limited due in part to the accumulation of HO in an arthrosis environment characterized by a sluggish metabolism. Here we develop a self-cascade nanomotor with high efficiency toward simultaneous uric acid (UA) degradation and HO elimination on the basis of UOx and sodium citrate loading in amine functionalized hollow mesoporous silica nanoparticles (AHMSNs). Due to the inherent asymmetry of AHMSNs, the developed nanomotors can be actuated by ionic diffusiophoresis induced by the enzymatic UA degradation, thus enlarging the diffusion range within the joint cavity.
View Article and Find Full Text PDFMaterial decomposition approaches for monosodium urate (MSU) quantification in gouty arthritis: a (bio)phantom study.
Eur Radiol Exp
November 2024
Department of Radiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.
Background: Dual-energy computed tomography (DECT) is a noninvasive diagnostic tool for gouty arthritis. This study aimed to compare two postprocessing techniques for monosodium urate (MSU) detection: conventional two-material decomposition and material map-based decomposition.
Methods: A raster phantom and an ex vivo biophantom, embedded with four different MSU concentrations, were scanned in two high-end CT scanners.
Rational design of Ag-doped MnFeO/HNTs for peroxidase-mimicking activity and colorimetric sensing of uric acid in human serum.
Talanta
January 2025
Department of Pharmacy, Jining Medical University, Rizhao 276826, Shandong, China. Electronic address:
Article Synopsis
- Researchers developed a new nanozyme using Ag-doped MnFeO and halloysite nanotubes (HNTs) that mimics enzyme functions and shows high catalytic activity and magnetic properties.
- The system efficiently detects uric acid (UA) by changing color from colorless to blue when UA is present, with a detection limit of 59 nM and a linear response for UA concentrations of 1 to 20 µM.
- The method successfully detected UA in human serum with over 99.68% recovery, showcasing a practical application for this innovative colorimetric sensing platform.
Investigation of gaseous end products produced by thulium fiber laser lithotripsy of cystine, uric acid, and calcium oxalate monohydrate stones: A gas chromatographic and electron microscopic analysis.
Urolithiasis
September 2024
Department of Urology, Necmettin Erbakan University Medical Faculty, Konya, Turkey.
Article Synopsis
- Laser lithotripsy can break down cystine stones, potentially producing toxic gas byproducts, specifically during the use of thulium fiber laser (TFL) but this has not been thoroughly studied.
- * An in vitro study was conducted to analyze the gases released when cystine stones were fragmented with TFL, revealing that gas formation only occurred with cystine stones, producing gases like sulfur and hydrogen sulfide.
- * Analysis of the remaining stone fragments showed they contained various chemical elements, pointing to a risk of toxic gas emissions that could affect patients and operating room staff during procedures.
Virtual noncontrast images reveal gouty tophi in contrast-enhanced dual-energy CT: a phantom study.
Eur Radiol Exp
June 2024
Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität Zu Berlin, Freie Universität Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Article Synopsis
- This study investigates how virtual noncontrast (VNC) images from dual-energy computed tomography (DECT) can improve the detection of monosodium urate crystals (MSU), which are indicative of gouty tophi, especially when high concentrations of iodinated contrast media (ICM) are used.
- Using various phantoms with different ICM and MSU concentrations, the research compared the effectiveness of VNC images against standard DECT images in identifying MSU.
- Results showed that VNC significantly enhances MSU detection when ICM levels are high, suggesting that VNC could effectively aid in diagnosing gout without needing traditional noncontrast image acquisitions.
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