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Clinico-Pathological Study of Symptomatic Hyperparathyroidism: Is it a Different Phenotype Expression of Hyperparathyroidism?
Indian J Otolaryngol Head Neck Surg
February 2025
Department of General Surgery, Amrita Institute of Medical Sciences, Amrita Hospitals, Kochi, Kerala India.
Despite the popularity of auto analyzers in urban areas of the country the incidence of asymptomatic hyperparathyroidism has not markedly increased and symptomatic diseases are regularly seen in all major institutions. The present single-institution analysis of proven hyperparathyroidism in the last 16 years was aimed at comparing the demographic, clinical, and pathological characteristics of symptomatic and asymptomatic primary hyperparathyroidism and comparing those with the asymptomatic diseases seen in developed countries. A retrospective chart review of 332 patients was done and 29 (8.
View Article and Find Full Text PDFClinico-Pathological Predictors Affecting Lymph Node Status in Oral Squamous Cell Carcinoma.
Indian J Otolaryngol Head Neck Surg
January 2025
Oral and Maxillofacial Surgery, Khandelwal Dental Clinic and Implant Center, Noida, Uttar Pradesh India.
To analyze the correlation of age, gender, subsite, and histopathological factors such as tumour grade, depth of invasion (DOI), lymphovascular invasion(LVI), perineural invasion(PNI), bone invasion and worst pattern of invasion(WPOI) with cervical lymph node metastasis(LNM), extranodal extension(ENE), lymph node ratio(LNR), number of positive nodes(+ veN) and T stage in oral squamous cell carcinoma (OSCC). We conducted a retrospective study on cases with OSCC of all stages and any designated anatomical subsite of the oral cavity, who reported to us from the year 2018-2023, and underwent curative-intent surgery with or without appropriate adjuvant treatment. Various clinic-pathological parameters were recorded and their correlation with lymph node metastasis, lymph node ratio(LNR), number of positive nodes(+ veN), extranodal extension(ENE) and T stage was analyzed.
View Article and Find Full Text PDFReliability of core needle biopsy for HER2-low early-stage breast cancer.
Clin Transl Oncol
March 2025
Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133, Milan, Italy.
Background: The reliability of core needle biopsy (CNB) for HER2-positive breast cancer is well established. However, data on HER2-low and the potential for inconsistencies with surgical samples are limited.
Materials And Methods: Concordance between CNB and surgical samples was assessed using the unweighted Cohen kappa statistic (Kc) in a consecutive series of 776 treatment-naïve early-stage breast cancer patients.
Real world experience with MET inhibitors in MET exon 14 skipping mutated non-small cell lung cancer: largest Indian perspective.
Discov Oncol
March 2025
Medical Oncology, Tata Memorial Hospital, Mumbai, India.
Background: Patients with Non-small Cell Lung Cancer (NSCLC) presenting with Mesenchymal-epithelial transition exon 14 skipping mutation (MET ex14) have an unfavorable prognosis with traditional therapies. MET inhibitors have altered the therapeutic paradigm of NSCLC. MET ex14 skipping alteration is reported in 3-4% cases (N Engl J Med 383(10):944-957, 2020, Cancer Discov 5(8):842-9, 2015).
View Article and Find Full Text PDFClinico-pathological characteristics of a distinct tumor phenotype: invasive lobular carcinoma with tubular elements (ILC-TE) in the WSG ADAPTcycle trial.
Lab Invest
March 2025
Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address:
Background: Invasive lobular carcinoma with tubular elements (ILC-TE) is a recently identified variant of invasive lobular breast carcinoma (ILC). The histology of ILC-TE is defined by non-cohesive carcinoma cells mixed with cohesive tubular elements and complete loss of E-cadherin. Cell-cell adhesion is partially restored by switching from an E-cadherin-deficient to a P-cadherin-proficient status (EPS).
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