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Splenic red pulp macrophages eliminate the liver-resistant from the blood circulation of mice.
Sci Adv
March 2025
Center for Infectious Biology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Invasive infections by encapsulated bacteria are the major cause of human morbidity and mortality. The liver resident macrophages, Kupffer cells, form the hepatic firewall to clear many encapsulated bacteria in the blood circulation but fail to control certain high-virulence capsule types. Here we report that the spleen is the backup immune organ to clear the liver-resistant serotypes of (pneumococcus), a leading human pathogen.
View Article and Find Full Text PDFIn vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity.
J Immunol
March 2025
Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Leukocytes migrate through the blood and extravasate into organs to surveil the host for infection or cancer. Recently, we demonstrated that intravenous (IV) anti-CD45.2 antibody labeling allowed for precise tracking of leukocyte migration.
View Article and Find Full Text PDFGenetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improves inflammatory arthritis outcomes.
Proc Natl Acad Sci U S A
March 2025
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, pannus formation, and progressive joint destruction. The inflammatory milieu in RA drives endothelial cell activation and upregulation of adhesion molecules, thus facilitating leukocyte infiltration into the synovium. Reelin, a circulating glycoprotein previously implicated in endothelial activation and leukocyte recruitment in diseases such as atherosclerosis and multiple sclerosis, has emerged as a potential upstream regulator of these processes.
View Article and Find Full Text PDFMitochondrial-Mediated Platelet Activation in Polymyalgia Rheumatica.
ACR Open Rheumatol
March 2025
Division of Rheumatology, University of Washington, Seattle, Washington, USA.
Objective: Platelet activation is thought to participate in polymyalgia rheumatica (PMR) pathogenesis. Upon platelet activation, mitochondria are expelled into the extracellular space. However, whether extracellular mitochondria are present in patients with PMR and whether they can induce platelet activation is not known.
View Article and Find Full Text PDFSurvey of West Nile virus infection in wildlife species in the Orinoquia region of Colombia.
Front Microbiol
February 2025
Laboratory of molecular studies of the Orinoquian region- LEMO, Facultad de Ciencias, Universidad Internacional del Trópico Americano, Universidad Internacional del Trópico Americano, Yopal, Colombia.
Studies focused on the epidemiological surveillance of arboviruses that cause potentially zoonotic diseases, such as dengue, Zika, or emerging viruses like West Nile virus (WNV), are critical due to their significant impact on public health. Although research on these infectious agents is increasing in Colombia, regions remain where the presence of zoonotic agents is still unknown. To address this knowledge gap, the present study aimed to investigate the current status of WNV circulation in wildlife in two municipalities of the department of Casanare (El Yopal and Paz de Ariporo) from the Colombian region of Orinoquia.
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