Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archotol.1971.00770070345004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
LRRC8/VRAC volume-regulated anion channels are crucial for hearing.
J Biol Chem
July 2024
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address:
Hearing crucially depends on cochlear ion homeostasis as evident from deafness elicited by mutations in various genes encoding cation or anion channels and transporters. Ablation of ClC‑K/barttin chloride channels causes deafness by interfering with the positive electrical potential of the endolymph, but roles of other anion channels in the inner ear have not been studied. Here we report the intracochlear distribution of all five LRRC8 subunits of VRAC, a volume-regulated anion channel that transports chloride, metabolites, and drugs such as the ototoxic anti-cancer drug cisplatin, and explore its physiological role by ablating its subunits.
View Article and Find Full Text PDFAnion efflux mediates transduction in the hair cells of the zebrafish lateral line.
Proc Natl Acad Sci U S A
December 2023
Department of Biology, The Whitney Laboratory for Marine Bioscience, University of Florida, Saint Augustine, FL 32080.
Article Synopsis
- Hair cells are crucial for hearing in vertebrates, converting sound into electrical signals through ion channels that allow cations to enter the cells.
- Zebrafish hair cells have been used as a model to study this process, based on the assumption they function similarly to other hair cells.
- This study reveals that zebrafish hair cells operate differently, relying on the outward flow of anions instead of cations, suggesting a need for more research to fully understand hair cell function across various species.
Otoprotection against aminoglycoside- and cisplatin-induced ototoxicity focusing on the upstream drug uptake pathway.
J Chin Med Assoc
January 2024
Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Aminoglycoside- and cisplatin-induced ototoxicity, which is a significant issue owing to the widespread use of these drugs in clinical practice, involves the entry of aminoglycosides and cisplatin into the endolymph and hair cells via specific channels or transporters, followed by reactive oxygen species (ROS) generation and hair cells apoptosis. Current strategies focalize primarily on interference with downstream ROS effects; however, recent evidence has demonstrated that inhibiting the uptake of aminoglycosides and cisplatin by hair cells is another promising strategy for tackling the upstream drug uptake pathway. With advances in structural biology, the conformations of certain aminoglycoside and cisplatin channels and transporters, such as the mechanoelectrical transduction channel and organic cation transporter-2, have been largely elucidated.
View Article and Find Full Text PDFKCCs, NKCCs, and NCC: Potential targets for cardiovascular therapeutics? A comprehensive review of cell and region specific expression and function.
Acta Histochem
May 2023
Department of Pharmacy, Silver Oak University, Ahmedabad, Gujarat 382481, India.
Cardiovascular diseases, the leading life-threatening conditions, involve cardiac arrhythmia, coronary artery disease, myocardial infarction, heart failure, cardiomyopathy, and heart valve disease that are associated with the altered functioning of cation-chloride cotransporters. The decreased number of cation-chloride cotransporters leads to reduced reactivity to adrenergic stimulation. The KCC family is crucial for numerous physiological processes including cell proliferation and invasion, regulation of membrane trafficking, maintaining ionic and osmotic homeostasis, erythrocyte swelling, dendritic spine formation, maturation of postsynaptic GABAergic inhibition, and inhibitory/excitatory signaling in neural tracts.
View Article and Find Full Text PDFInner hair cell stereocilia are embedded in the tectorial membrane.
Nat Commun
May 2021
Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Mammalian hearing depends on sound-evoked displacements of the stereocilia of inner hair cells (IHCs), which cause the endogenous mechanoelectrical transducer channels to conduct inward currents of cations including Ca. Due to their presumed lack of contacts with the overlaying tectorial membrane (TM), the putative stimulation mechanism for these stereocilia is by means of the viscous drag of the surrounding endolymph. However, despite numerous efforts to characterize the TM by electron microscopy and other techniques, the exact IHC stereocilia-TM relationship remains elusive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!