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The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on bile formation in the hamster. Studies were carried out at 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. A significant elevation in bile flow (+20%) and in the biliary output of glutathione (+34%), bile acid (+59%), cholesterol (+108%), phospholipids (+99%) and alkaline phosphatase (+36%) was observed in the infected animals.

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[Effect of chronic administration of cyclosporin A on choleresis in rats].

Gastroenterol Clin Biol

October 1989

Unité de Recherches de Physiopathologie Hépatique, INSERM U 24, Clichy.

The effect of therapeutic doses of cyclosporine A (CyA) on bile flow and bile salt output was studied in the rat. Thirty male Sprague-Dawley rats (250 to 380 g) were injected intraperitoneally with CyA (n = 15) or vehicle (n = 15) at the dose of 10 mg.kg-1 for 3 weeks.

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Importance of carbonic anhydrase for canalicular and ductular choleresis in the pig.

Acta Physiol Scand

August 1988

University of Oslo, Institute for Experimental Medical Research, Ullevaal Hospital, Norway.

To assess the importance of carbonic anhydrase (CA) for canalicular and ductular choleresis, the effect of acetazolamide on bile secretion was measured in three experimental groups of anaesthetized pigs. CA activity in liver homogenate was 46 (43-54) U g-1 wet weight, 150 mg kg-1 b.w.

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[Effect of water containing calcium and magnesium sulfates on the elimination of cholesterol in the rat].

Arch Int Physiol Biochim

June 1988

Laboratoire de Pharmacodynamie et Hydrologie, UER des Sciences Pharmaceutiques, Bordeaux.

In the rat, the activity of the thermal water of Capvern and of its ionic components on the modification of the flow rate and composition of hepatic bile has been investigated. Two groups of rats were selected: the first group received per os an overload of the thermal water during six weeks. At that time on empty stomach a great increase of biliary phospholipids was observed.

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Diethyl maleate (DEM) is known to produce a rapid depletion of hepatic glutathione (GSH) and to induce an immediate short-term choleresis in experimental animals. The aim of our investigation was to ascertain in rats the effect of DEM on biliary lipid composition during the increment in bile flow. Biochemical and morphological studies of liver tissue were conducted in parallel.

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