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Evaluation of renal functional reserve with oral protein load or new ultrasound test.
J Nephrol
January 2025
Department of Medicine, Surgery and Neurosciences, Nephrology, Dialysis and Transplantation Unit, University Hospital of Siena, Siena, Italy.
Background: Renal functional reserve (RFR) measures the difference between the stimulated glomerular filtration rate (GFR) and the baseline GFR to detect early signs of renal functional decline. The protein load test (RFR-T) is the gold standard for RFR assessment but is a complicated procedure. Renal intraparenchymal resistance index (RRI) variation test (DRRI-T) is a non-invasive method to measure renal function reserve using ultrasound.
View Article and Find Full Text PDFRenal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes.
Diabetes
January 2025
Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC Canada H2X 0A9.
The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule-specific deletion of angiotensinogen (Agt; RT-Agt-/-) in both Akita and streptozotocin (STZ)-induced mouse model of diabetes. Both Akita RT-Agt-/- and STZ-RT-Agt-/- mice exhibited significant attenuation of glomerular hyperfiltration, urinary albumin/creatinine ratio, glomerulomegaly and tubular injury.
View Article and Find Full Text PDFUnderstanding fluid dynamics and renal perfusion in acute kidney injury management.
J Clin Monit Comput
August 2024
Department of Anesthesia and Intensive Care Medicine, IRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano - Milan, 20089, Italy.
Article Synopsis
- Acute kidney injury (AKI) significantly increases the risk of serious health issues and costs in healthcare, affecting up to 50% of ICU patients, especially the elderly and those with existing health problems.
- Maintaining proper blood flow and auto-regulation in the kidneys is crucial, influenced by various neurohormonal processes and the tubuloglomerular feedback mechanism.
- Effective management of AKI includes careful fluid management to avoid complications like volume overload, with the review offering insights on managing fluid, utilizing biomarkers, and potential drug treatments.
Effects of intrarenal pelvic infusion of tumour necrosis factor-α and interleukin 1-β on reno-renal reflexes in anaesthetised rats.
J Hypertens
June 2024
Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.
Objective: Reno-renal reflexes are disturbed in cardiovascular and hypertensive conditions when elevated levels of pro-inflammatory mediators/cytokines are present within the kidney. We hypothesised that exogenously administered inflammatory cytokines tumour necrosis factor alpha (TNF-α) and interleukin (IL)-1β modulate the renal sympatho-excitatory response to chemical stimulation of renal pelvic sensory nerves.
Methods: In anaesthetised rats, intrarenal pelvic infusions of vehicle [0.
Anji white tea relaxes precontracted arteries, represses voltage-gated Ca channels and voltage-gated K channels in the arterial smooth muscle cells: Comparison with green tea main component (-)-epigallocatechin gallate.
J Ethnopharmacol
June 2024
Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan, 030001, Shanxi Province, China. Electronic address:
Article Synopsis
- Tea is a globally popular drink, and its extracts, particularly EGCG from green tea, are studied for their effects on vascular health, necessitating further investigation into Anji white tea's properties.
- The study aimed to assess the vasomotion effects of Anji white tea and EGCG, focusing on the roles of voltage-gated calcium and potassium channels in these effects.
- Results showed that Anji white tea significantly relaxed various rat arteries, while EGCG appeared to enhance precontraction in many cases, indicating a complex relationship between tea components and vascular response.
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