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Full recovery from a potentially lethal dose of orphenadrine ingestion using conservative treatment: a case report.
Hum Exp Toxicol
November 2010
Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Intoxication by orphenadrine is uncommon. The clinical features consist of both central and peripheral anticholinergic effects. Ingestion of 2 to 3 g orphenadrine in an adult has been associated with fatality.
View Article and Find Full Text PDF[Clinical pharmacology of anticholinergic antiparkinson agents. A review with emphasis on acute toxicity].
Tidsskr Nor Laegeforen
January 1998
Psykiatrisk avdeling, Telemark sentralsjukehus, Skien.
Today, anticholinergic antiparkinsonian drugs are primarily used to ameliorate extrapyramidal side-effects induced by neuroleptic agents. Orphenadrine dominates quantitatively among these drugs in Norway, presumably because it is assumed to carry a lower risk of abuse. There are numerous reports of deaths following orphenadrine overdoses.
View Article and Find Full Text PDFEfficacy of injectable anticholinergic drugs against soman-induced convulsive/subconvulsive activity.
Drug Chem Toxicol
September 1994
U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5425.
Six FDA approved, injectable compounds [benztropine (BZT); biperiden (BIP); dicyclomine (DCL); l-hyoscyamine (HYO); orphenadrine (ORP); scopolamine (SCP)] were each compared to diazepam (DZ, the standard) in male guinea pigs against ongoing soman-induced convulsive or sub-CV (CV/sub-CV) activity. Three trained graders concurrently assigned CV/sub-CV scores to each animal based on signs of intoxication at various times post-soman. Animals received (im) pyridostigmine (26 micrograms/kg) 30 min before soman (56 micrograms/kg; 2 x LD50), atropine (2 mg/kg) admixed with 2-PAM (25 mg/kg) at one min after soman, and the candidate drug preparation at 5.
View Article and Find Full Text PDFThe number of deaths as a consequence of orphenadine poisoning seems to increase, mostly among severely psychotic males. The lethal dose corresponds to the weekly average dose used in the treatment of neuroleptic extrapyramidal side effects. Based on the literature, the serious, rapidly incipient, cardiac, and neurologic symptoms of poisoning are emphasized.
View Article and Find Full Text PDFA case of lethal orphenadrine intoxication is reported. Included are the anatomical and toxicological findings. Most conspicuous histologically was the centrilobular necrosis of the liver.
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