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Female Brain and Endocrinological Research-Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health outcomes in female veterans for future intervention success.
PLoS One
January 2025
Female Brain & Endocrine Health Research (FemBER) Consortium.
Background: Recent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a diagnosis of psychiatric (trauma, alcoholism, depression), and/or a physical health condition (brain injury, insomnia, diabetes). Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. Further, they call for a better understanding of the underlying biopsychosocial mechanisms that might confer heightened risk for female veterans, to tailor preventative and interventional strategies that support brain health across the lifespan.
View Article and Find Full Text PDFNanotheranostics in Breast Cancer Bone Metastasis: Advanced Research Progress and Future Perspectives.
Pharmaceutics
November 2024
Department of Breast Surgery, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital and Institute, Shenyang 110042, China.
Breast cancer is the leading cause of cancer-related morbidity and mortality among women worldwide, with bone being the most common site of all metastatic breast cancer. Bone metastases are often associated with pain and skeletal-related events (SREs), indicating poor prognosis and poor quality of life. Most current therapies for breast cancer bone metastasis primarily serve palliative purposes, focusing on pain management, mitigating the risk of bone-related complications, and inhibiting tumor progression.
View Article and Find Full Text PDFState of Knowledge About Thyroid Cancers in the Era of COVID-19-A Narrative Review.
Biomedicines
December 2024
Clinical Department of Diabetology, Hypertension and Internal Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Thyroid cancer (TC), due to its heterogeneous nature, remains a clinical challenge. Many factors can initiate the carcinogenesis process of various types of TC, which complicates diagnosis and treatment. The presented review gathers current information on specific types of TC, taking into account the effects of the COVID-19 pandemic.
View Article and Find Full Text PDFEmerging treatment strategies in dry eye disease: Potential of blood-derived approaches and natural plant-based products.
Exp Eye Res
December 2024
Department of Medical Physics, Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Dry eye disease (DED) is a common ocular condition characterized by chronic inflammation and tear film disruption. It affects millions of people worldwide, causing significant eye discomfort and vision disturbances. Despite its prevalence, DED remains a complex condition that is not yet fully understood.
View Article and Find Full Text PDFInterleukin-17 Inhibitors in the Treatment of Hidradenitis Suppurativa.
BioDrugs
January 2025
Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
Article Synopsis
- * The IL-17 pathway has been identified as a key player in HS inflammation, leading to the development of IL-17 inhibitors like secukinumab and bimekizumab, both of which have gained regulatory approvals for treating moderate-to-severe HS.
- * Ongoing clinical trials are exploring newer drugs like sonelokimab and izokibep, which show promise in treating HS, while this review summarizes the latest findings and advancements in understanding
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