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Computational Fluid Dynamics (CFD) Modeling of Material Transport through Triply Periodic Minimal Surface (TPMS) Scaffolds for Bone Tissue Engineering.
J Biomech Eng
January 2025
Department of Mechanical Engineering Marshall University, Huntington, WV 25755, USA; Department of Biomedical Engineering Marshall University, Huntington, WV 25755, USA.
Cell-laden, scaffold-based tissue engineering methods have been successfully utilized for the treatment of bone fractures. In such methods, the rate of scaffold biodegradation, transport of nutrients, and removal of cell metabolic wastes are critical fluid-dynamics factors, affecting tissue regeneration. Therefore, there is a critical need to identify the underlying material transport mechanisms associated with stem cell-driven, scaffold-based bone tissue regeneration.
View Article and Find Full Text PDFAtomistic adsorption of PETase onto large-scale PET 3D-models that mimic reality.
Phys Chem Chem Phys
January 2025
LAQV@REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
Polyethylene terephthalate (PET) has been widely used in plastic products, leading to massive PET waste accumulation in ecosystems worldwide. Efforts to find greener processes for dealing with post-consumer PET waste led to the discovery of PET-degrading enzymes such as PETase (PETase). studies have provided valuable contributions to this field, shedding light on the catalytic mechanisms and substrate interactions in many PET hydrolase enzymes.
View Article and Find Full Text PDFBOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI.
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C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Background: Cerebrospinal fluid (CSF) motion and pulsatility has been proposed to play a crucial role in clearing brain waste. Although its driving forces remain debated, increasing evidence suggests that large amplitude vasomotion drives such CSF fluctuations. Recently, a fast blood-oxygen-level-dependent (BOLD) fMRI sequence was used to measure the coupling between CSF fluctuations and low-frequency hemodynamic oscillations in the human cortex.
View Article and Find Full Text PDFThe Effect of Lean Hospital Practices on Nurses' Direct Care Activities: Time and Motion Study.
J Eval Clin Pract
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Institute of Health Sciences, Marmara University, Istanbul, Turkey.
Background: This study investigates the effects of lean management practices on nurses' direct patient care activities and the interruptions they encounter in healthcare settings. The literature indicates that lean management enhances efficiency and improves patient care. Increased nursing time per patient correlates with better outcomes; however, rising patient loads and frequent interruptions hinder nurses' ability to deliver effective care, jeopardising patient safety.
View Article and Find Full Text PDFA pain research strategy for Europe: A European survey and position paper of the European Pain Federation EFIC.
Eur J Pain
January 2025
UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Background: Pain is the leading cause of disability and reduced quality of life worldwide. Despite the increasing burden for patients and healthcare systems, pain research remains underfunded and under focused. Having stakeholders identify and prioritize areas that need urgent attention in the field will help focus funding topics, reduce 'research waste', improve the effectiveness of pain research and therapy and promote the uptake of research evidence.
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