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Combined immune checkpoint blockade (ICB) and chemoradiation (CRT) is approved in patients with locally advanced cervical cancer (LACC) but optimal sequencing of CRT and ICB is unknown. NRG-GY017 (NCT03738228) was a randomized phase I trial of atezolizumab (anti-PD-L1) neoadjuvant and concurrent with CRT (Arm A) vs. concurrent with CRT (Arm B) in patients with high-risk node-positive LACC.
View Article and Find Full Text PDFClinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinoma.
JTCVS Open
December 2024
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Objective: To identify clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinoma (LUAD) and to evaluate survival after brain metastasis.
Methods: Patients who underwent complete resection of stage I-IIIA LUAD between 2011 and 2020 were included. A subset of patients had broad-based panel next-generation sequencing performed on their tumors.
A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury.
Sci Rep
December 2024
Resuscitation Science Center and Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Pediatric neurological injury and disease is a critical public health issue due to increasing rates of survival from primary injuries (e.g., cardiac arrest, traumatic brain injury) and a lack of monitoring technologies and therapeutics for treatment of secondary neurological injury.
View Article and Find Full Text PDFComprehensive characterization of European house dust contaminants: Concentrations and profiles, geographical variability, and implications for chemical regulation and health risk.
Sci Total Environ
December 2024
Flemish Institute for Technological Research (VITO), Unit Materials and Chemistry (MATCH), 2400 Mol, Belgium.
Article Synopsis
- - This study explores the levels and geographical differences of contaminants found in house dust across Europe, identifying over 1200 anthropogenic compounds using advanced techniques like mass spectrometry and suspect screening.
- - The research indicates that contaminant concentrations vary less than threefold within Europe, showing similarities with North American dust due to shared consumer products and materials.
- - It highlights geographical patterns, revealing that certain contaminants increased from north to south (like PAHs and chlorinated paraffins), whereas others, like biocides, decreased; it also emphasizes a significant risk from older, restricted contaminants, like DEHP and PCBs, despite limited toxicity data available for newer compounds.
Clinical Outcomes of Maintenance Durvalumab After Definitive Concurrent Chemoradiotherapy in Unresectable Locally Advanced Stage III NSCLC According to EGFR and ALK Status: Korean Cancer Study Group LU-22-18.
JTO Clin Res Rep
December 2024
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Article Synopsis
- - The study investigates the effectiveness of durvalumab maintenance therapy in patients with unresectable locally advanced non-small cell lung cancer (NSCLC) after receiving concurrent chemoradiotherapy (CCRT), comparing those with specific genetic mutations to those without.
- - A total of 339 patients were analyzed, revealing similar progression-free survival (PFS) rates of 21.4 months for wild-type and 21.0 months for mutant groups, while significant differences in PFS were noted based on programmed death-ligand 1 (PD-L1) expression levels.
- - The findings suggest that while genetic mutations did not significantly alter outcomes, PD-L1 expression levels had a notable impact on PFS, highlighting the importance
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