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Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs.
Eur J Pharm Biopharm
November 2024
Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, Université de Liège, 4000 Liège, Belgium.
High solubility in water and physiological fluids is an indispensable requirement for the pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well established that pharmaceutical substances exhibiting limited solubility in water are inclined towards diminished and inconsistent absorption following oral administration, consequently resulting in variability in therapeutic outcomes. The current advancements in combinatorial chemistry and pharmaceutical design have facilitated the creation of drug candidates characterized by increased lipophilicity, elevated molecular size, and reduced aqueous solubility.
View Article and Find Full Text PDFScience- and risk-based strategy to qualify prefillable autoclavable syringes as primary packaging material.
Eur J Hosp Pharm
September 2022
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.
Objectives: To develop a science and risk based strategy to qualify a prefillable autoclavable cyclic olefin polymer (COP) syringe as a container for multiple drug products in a hospital pharmacy setting METHODS: Different extraction studies were performed with different solution characteristics: phosphate buffer batches (NaHPO / NaHPO in NaCl 0.9%) at different pH values, NaCl 0.9% batches, isopropyl alcohol (IPA) 5% in water and batches with Water For Injections (WFI) at different pH values.
View Article and Find Full Text PDFDevelopment of a zero-order sustained-release tablet containing mesalazine and budesonide intended to treat the distal gastrointestinal tract in inflammatory bowel disease.
Eur J Pharm Biopharm
June 2016
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address:
Ulcerative colitis (UC) and Crohn's disease (CD) are diseases affecting the gastrointestinal tract. Treatment depends on the severity of the disease, site of inflammation, and patient's response. The aim of this study was to develop a zero-order sustained-release tablet containing both the anti-inflammatory drugs mesalazine and budesonide as a new treatment option for ileo-colonic CD and UC.
View Article and Find Full Text PDFOromucosal film preparations: points to consider for patient centricity and manufacturing processes.
Expert Opin Drug Deliv
October 2016
a Institute of Pharmaceutics and Biopharmaceutics , Heinrich-Heine-University Düsseldorf, Düsseldorf , Germany.
Introduction: According to the European Pharmacopoeia, oromucosal films comprise mucoadhesive buccal films and orodispersible films. Both oral dosage forms receive considerable interest in the recent years as commercially available pharmaceutical products and as small scale personalized extemporaneous preparations.
Areas Covered: In this review, technological issues such as viscosity of the casting liquid, mechanical properties of the film, upscaling and the stability of the casting solution and produced films will be discussed.
Compatibility of medications during multi-infusion therapy: A controlled in vitro study on a multilumen infusion device.
Anaesth Crit Care Pain Med
April 2015
Department of Biopharmacy, Galenic and Hospital Pharmacy, Lille 2 University, UDSL, EA GRITA, UFR Pharmacie, 59037 Lille, France; Department of Pharmacy, CHRU Lille, 59037 Lille, France.
Objective: Drug incompatibilities can jeopardize the safety and effectiveness of intravenous drug therapies, especially in the field of anaesthesia and intensive care. Patients receive many drugs simultaneously through limited venous accesses. This study was designed to confirm the impact of a multilumen infusion device on the occurrence of known physical drug incompatibilities.
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