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Emerging therapies in the medical management of thyroid eye disease.
Front Ophthalmol (Lausanne)
December 2023
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, United States.
Introduction: Thyroid eye disease (TED) is an immune-mediated disorder associated with a heterogenous array of manifestations that may unfavorably impact vision and quality of life. As understanding of this entity's complex pathogenesis has evolved, so have therapies with novel molecular targets offering promise for improved patient outcomes.
Results: Emerging immunologic therapies for the management of thyroid eye disease have diverse mechanisms of actions and routes of administration.
Thyroid Hormone Homeostasis in Levothyroxine-treated Patients: Findings From ELSA-Brasil.
J Clin Endocrinol Metab
September 2024
Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, The University of Chicago, Chicago, IL 60637, USA.
Context: The effectiveness of levothyroxine (LT4) in restoring thyroid hormone (TH) homeostasis, particularly serum thyroxine (T4) and triiodothyronine (T3) levels, remains debatable.
Objective: This work aimed to assess TH homeostasis in LT4-treated individuals using data from the Longitudinal Study of Adult Health in Brazil (ELSA-Brasil) study.
Methods: The ELSA-Brasil study follows 15 105 adult Brazilians (aged 35-74 years) over 8.
Causal effects of lipid-lowering therapies on aging-related outcomes and risk of cancers: a drug-target Mendelian randomization study.
Aging (Albany NY)
December 2023
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Despite the widespread use of statins, newer lipid-lowering drugs have been emerging. It remains unclear how the long-term use of novel lipid-lowering drugs affects the occurrence of cancers and age-related diseases.
Methods: A drug-target Mendelian randomization study was performed.
Can Ashwagandha Benefit the Endocrine System?-A Review.
Int J Mol Sci
November 2023
Department of Orthopedics and Traumatology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland.
, also known as Ashwagandha, has been used in traditional medicine for thousands of years. Due to the wide range of its activities, there has been interest in its possible beneficial effects on the human body. It is proved that, among others, Ashwagandha has anti-stress, anti-inflammatory, antimicrobial, anti-cancer, anti-diabetic, anti-obesity, cardioprotective, and hypolipidemic properties.
View Article and Find Full Text PDFEffects of L. Polyphenols on the Animal Welfare and Milk Quality in Dairy Cows.
Animals (Basel)
October 2023
Department of Sciences and Technologies (DST), University of Sannio, 82100 Benevento, BN, Italy.
Here, we evaluated the effect of dietary supplementation with an L. extract on the animal welfare and milk quality of dairy cows. Thirty Italian Holstein-Friesian dairy cows in the mid-lactation phase (90 to 210 days) were blocked into experimental groups based on parity class (namely, primiparous (P) (n = 10), secondiparous (S) (n = 10) and pluriparous (PL) (n = 10)) and received, for 60 days, Phenofeed Dry at 500 mg/cow/day.
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