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Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride.
J Colloid Interface Sci
April 2025
School of Health Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Hypothesis: Nanoscale characterisation of the self-associated species formed by amphiphilic pharmaceuticals in aqueous solution carries relevance across their entire journey from development through to manufacture - relevant, therefore, not only as regards formulation of the drug products as medicines, but also potentially relevant to their bioavailability, activity, and clinical side effects. Such knowledge and understanding, however, can only be fully secured by applying a range of experimental and theoretical methodologies.
Experiments: Herein, we apply a synergistic combination of solubility, surface tension, SANS, NMR and UV spectroscopic studies, together with MD simulation and QM calculations, to investigate the meso-structures of propranolol hydrochloride aggregates in bulk aqueous solutions, at concentrations spanning 2.
Combining treatments for migraine prophylaxis: the state-of-the-art.
J Headache Pain
December 2024
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Combination treatments for migraine prophylaxis present a promising approach to addressing the diverse and complex mechanisms underlying migraine. This review explores the potential of combining oral conventional prophylactics, onabotulinumtoxin A, monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway, and small molecule CGRP receptor antagonists (gepants). Among the most promising strategies, dual CGRP inhibition through mAbs and gepants may enhance efficacy by targeting both the CGRP peptide and its receptor, while the combination of onabotulinumtoxin A with CGRP treatments offers synergistic pain relief.
View Article and Find Full Text PDFMetabolomic insights into rhizosphere soil carbon component variations of Phragmites communis in the exposure of propranolol.
Sci Total Environ
December 2024
Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, Hohai University, Nanjing 210098, People's Republic of China; College of Environment, Hohai University, Nanjing 210098, People's Republic of China.
Propranolol (PRO) has been detected in water bodies worldwide, attributed to the incomplete removal by wastewater treatment processes. Although reports exist on the removal of PRO by wetland plants such as Phragmites communis, research on the impact of PRO on soil organic carbon (SOC) components in these plants' rhizospheres remains scarce. This investigation examined the impacts of 0.
View Article and Find Full Text PDFImpact of Tumoral β2-Adrenergic Receptor Expression on Chemotherapeutic Response and Prognosis in Patients with Advanced Colorectal Cancer.
Ann Surg Oncol
September 2024
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Article Synopsis
- The study investigates the role of the β2-adrenergic receptor (β2-AR) as a potential marker for chemosensitivity and a new therapeutic target in advanced colorectal cancer (CRC) treated with chemotherapy.
- Researchers analyzed β2-AR expression in 80 advanced CRC cases and found that high levels of this receptor were linked to poorer patient outcomes and resistance to certain chemotherapy drugs.
- The findings suggest that existing β-blockers like propranolol might enhance treatment effectiveness, especially when combined with drugs like bevacizumab in CRC cases resistant to standard therapies.
Photophysical Response of Propranolol in Biomimetic Micellar Media of Alkyltrimethylammonium Bromide Surfactants: Effect of pH and Alkyl Chain Length.
J Fluoresc
August 2024
Department of Chemistry, Sikkim Manipal Institute of Technology, Sikkim Manipal University, Sikkim, India.
The photophysical behavior of a β-blocker drug propranolol (PPL) in micellar environments, formed by alkyltrimethylammonium bromide surfactants viz.; Cetyltrimethylammonium bromide (CTAB), Tetradecyltrimethylammonium bromide (TTAB), and Dodecyltrimethylammonium bromide (DTAB), has been investigated through fluorescence and UV-visible spectroscopic techniques at pH levels of 3.5, 7.
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