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An hiPSC-CM approach for electrophysiological phenotyping of a patient-specific case of short-coupled TdP.
Stem Cell Res Ther
December 2024
Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Introduction: A healthy young woman, age 26 without prior cardiac complications, experienced an out-of-hospital cardiac arrest caused by ventricular fibrillation (VF), which coincided with a fever. Comprehensive diagnostics including echo, CMR, exercise testing, and genetic sequencing, did not identify any potential cause. This led to the diagnosis of idiopathic VF and installment of an implantable cardioverter defibrillator, which six months later appropriately intervened another VF episode under conditions comparable to the first event.
View Article and Find Full Text PDFA case report of familial catecholaminergic polymorphic ventricular tachycardia with a novel mutation in the ryanodine receptor 2.
Eur Heart J Case Rep
December 2024
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is suspected by clinical characteristics involving fatal arrhythmic events in childhood and adolescence. On the other hand, genetic testing is also important because the mutation site in the specific genes of CPVT is related to the risk of ventricular arrhythmias and gene penetrance.
Case Summary: We present a case of a 15-year-old male with a familial history of CPVT and a history of syncope at the age of 5.
Factors related to the choice of warfarin for treating newly diagnosed nonvalvular atrial fibrillation are associated with safety outcomes during anticoagulation: A new-user, active-comparator, retrospective cohort study.
J Arrhythm
December 2024
Department of Clinical Research and Management, Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan.
Background: Direct oral anticoagulants (DOACs) are preferred for stroke prevention in nonvalvular atrial fibrillation (NVAF); however, warfarin is still used. This study examined why physicians may choose warfarin over DOACs and the associated safety outcomes in patients with NVAF.
Methods: We conducted a new-user, active-comparator cohort study in newly diagnosed patients with NVAF to assess safety outcomes after the introduction of DOACs in Japan.
A case report of verapamil toxicity leading to haemodynamic compromise in obstructive hypertrophic cardiomyopathy.
Eur Heart J Case Rep
December 2024
Department of Medicine, Division of Cardiology, University of California, Irvine, 333 City Blvd W, Orange, CA 92868, USA.
Background: Hypertrophic cardiomyopathy (HCM) is an inherited condition characterized by left ventricular (LV) hypertrophy unexplained by increased afterload, often with concomitant outflow tract obstruction. Verapamil is commonly used to treat symptomatic patients. However, its potential for adverse effects should be recognized.
View Article and Find Full Text PDFElectrical storm induced by premature ventricular beat with extremely short coupling interval in a patient with long QT syndrome type 3.
J Electrocardiol
November 2024
Division of Pediatric Cardiology, Department of Pediatrics, Iwate Medical University, Yahaba, Japan.
Article Synopsis
- A 10-year-old boy with long QT syndrome type 3 (LQT3) experienced severe episodes of torsade de pointes (TdP) associated with fast ventricular arrhythmias.
- After replacing his implantable cardioverter-defibrillator, he faced an "electrical storm" that didn't improve even with rapid heart pacing.
- Treatment with dexmedetomidine and verapamil successfully controlled the TdP, emphasizing the need to address specific rapid arrhythmias in patients with LQT3.
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