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Re-encountering the phobic cue within days after a reconsolidation intervention is crucial to observe a lasting fear reduction in spider phobia.
Mol Psychiatry
January 2025
Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Memory reconsolidation interventions offer an exciting alternative to exposure treatment because they may target fear memories directly, thereby preventing relapse. A previous reconsolidation intervention for spider fear abruptly reduced avoidance behaviour, whereas changes in self-reported fear followed later. In this pre-registered placebo-controlled study, we first aimed to conceptually replicate these effects in spider phobia.
View Article and Find Full Text PDFAcute Muscle Weakness in Graves' Disease: A Case Report of Hypokalemic Thyrotoxic Periodic Paralysis.
Cureus
November 2024
Emergency Medicine, Mayo Clinic Arizona, Phoenix, USA.
Thyrotoxic periodic paralysis (TPP) is a rare but significant complication of hyperthyroidism, characterized by episodes of muscle weakness or paralysis and associated hypokalemia. This case report details a 30-year-old Latin American male with a history of Graves' disease, presenting with acute muscle weakness and hypokalemia. The patient reported transient episodes of weakness over recent weeks, culminating in a severe episode prompting emergency evaluation.
View Article and Find Full Text PDFComprehensive approach to esophageal variceal bleeding: From prevention to treatment.
World J Gastroenterol
November 2024
Department of Medicine and Surgery, University of Enna 'Kore', Enna 94100, Sicilia, Italy.
Esophageal variceal bleeding is a severe complication often associated with portal hypertension, commonly due to liver cirrhosis. Prevention and treatment of this condition are critical for patient outcomes. Preventive strategies focus on reducing portal hypertension to prevent varices from developing or enlarging.
View Article and Find Full Text PDFFemoral Artery Infusion of αMSH Increases Muscle Thermogenesis and Promotes Glucose Uptake in Ovariectomized Ewes.
Endocrinology
November 2024
Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Article Synopsis
- The melanocortin system plays a crucial role in controlling energy balance and weight regulation, with recent findings indicating its effects on peripheral tissues like skeletal muscle, independent of the brain or SNS.
- Infusing α-melanocyte-stimulating hormone (αMSH) directly into the femoral artery significantly increased heat production in skeletal muscle, while not affecting food intake, demonstrating its local action in energy expenditure.
- The study also revealed that αMSH infusion enhanced mitochondrial function, increased glucose uptake in skeletal muscle, and showed that blocking SNS with certain drugs did not impact αMSH's effects, highlighting its unique role in energy regulation.
Safety of Prior Propranolol Therapy for Infantile Hemangioma.
Pediatr Dermatol
November 2024
Department of Dermatology, West Virginia University, Morgantown, West Virginia, USA.
Article Synopsis
- * A study using the TrinetX database looked at children aged 10-17 who received propranolol for IH and assessed risks of growth impairment, sleep disorders, learning disabilities, and diabetes mellitus.
- * The results indicated no significant long-term risks for these adverse effects in children treated with propranolol for IH during infancy, supporting the medication's safety.
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