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Benzyl Ammonium Carbamates Undergo Two-Step Linker Cleavage and Improve the Properties of Antibody Conjugates.
Angew Chem Int Ed Engl
December 2024
Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702, USA.
Targeted payload delivery strategies, such as antibody-drug conjugates (ADCs), have emerged as important therapeutics. Although considerable efforts have been made in the areas of antibody engineering and labeling methodology, improving the overall physicochemical properties of the linker/payload combination remains an important challenge. Here we report an approach to create an intrinsically hydrophilic linker domain.
View Article and Find Full Text PDFVarious physiological functions and reaction cascades, as well as disease progression in the living systems, are controlled by the activity of specific proteolytic enzymes. We conducted the study to evaluate protease activity by assessing peptide fragments from either conserved or labeled red blood cells (RBCs) with aminofluorescein (AF) in the reaction media. RBCs were incubated in media containing trypsin.
View Article and Find Full Text PDFEffects of preservatives on the activities of salivary enzymes.
Arch Oral Biol
January 2025
Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea; Institute of Aging, Seoul National University, Seoul, South Korea. Electronic address:
Article Synopsis
- The study aimed to examine how common preservatives in oral health products impact the enzymatic activities of three enzymes: lysozyme, peroxidase, and α-amylase, both in solution and on the surface of hydroxyapatite beads.
- Four preservatives were tested: sodium benzoate, methylparaben, propylparaben, and benzalkonium chloride, using sources like hen egg-white lysozyme and human saliva for enzyme activity measurements.
- Results showed that parabens significantly decreased peroxidase and lysozyme activity in solution, while sodium benzoate and benzalkonium chloride were deemed better preservatives than parabens based on their effects on salivary enzymes.
A high-efficiency and selective fluorescent assay for the detection of tetracyclines.
Sci Rep
October 2024
Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, 253023, China.
Tetracyclines (TCs) rank second globally in the use of animal infection therapy and animal husbandry as growth promoters among all antibiotics. However, large amounts of TCs residue in food products and more than 75% of TCs are excreted into the environment, causing adverse effects on the ecological system and human health. It has been challenging to simultaneously realize low-cost, rapid, and highly selective detection of TCs.
View Article and Find Full Text PDFA novel coumarin-naphthalimide-based ratiometric fluorescent probe for efficiently monitoring of hydrazine in environmental water.
Luminescence
September 2024
School of Chemistry and Chemical Engineering, North University of China, Taiyuan, China.
A novel coumarin-naphthalimide-based ratiometric fluorescent probe, called XPT, was synthesized with the aim of achieving high sensitivity and anti-interference for NH detection. The probe XPT consists of coumarin species and naphthalimide species, which act as the energy donor and acceptor, respectively. The phthalimide group functions as the recognition unit for NH.
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