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Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure.
Toxicology
December 2024
Department of Zoology, IIS (Deemed to be University), Jaipur, Rajasthan, India.
In the present study, co-parental exposure to polystyrene nanoplastics (PS-NPs) elicits profound teratological impacts, including skeletal and visceral malformations, post-natal effects on neonatal growth and neurobehavioral development in F1 progeny. A comprehensive investigation was conducted on Swiss albino mice fetuses, neonates (PND 1-21) and adult mice offsprings (PND 60) following parental exposure during spermatogenesis and oogenesis period, as well as continued maternal exposure during gestation and weaning. The parental mice were administered PS-NPs via oral gavage at low dose (0.
View Article and Find Full Text PDFExposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment.
Int J Toxicol
December 2024
Department of Zoology, Bangalore University, Bangalore, India.
Neuroendocrine regulation is disrupted by di-n-butyl phthalate (DBP) when exposure occurs during the critical periods of fetal development, which can lead to neurological disorders. To evaluate the toxic potential of DBP, it is necessary to conduct teratological studies, which could determine impacts on the development of the fetus. The present study was designed to understand the sequelae of neuroendocrine regulation in one-month-old pups when rats were exposed to DBP (F-F) and during lactation.
View Article and Find Full Text PDFThrough a teratological lens: A narrative review of exposure to stress and drugs of abuse during pregnancy on neurodevelopment.
Neurotoxicol Teratol
September 2024
Slippery Rock University, Department of Psychology, 1 Morrow Way, Slippery Rock, PA 16057, United States of America.
Teratological research shows that both prenatal stress and prenatal substance exposure have a significant impact on neurodevelopmental outcomes in children. Using human research, the purpose of this narrative review is to explore the degree to which these exposures may represent complex prenatal and postnatal risks for the development of cognition and behavior in children. An understanding of the HPA axis and its function during pregnancy as well as the types and operationalization of prenatal stress provide a context for understanding the direct and indirect mechanisms by which prenatal stress affects brain and behavior development.
View Article and Find Full Text PDFPrenatal exposure to ethion caused maternal and foetal toxicity in rats.
Reprod Toxicol
June 2024
Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
Article Synopsis
- * Pregnant rats were divided into five groups, receiving different doses of ethion; results showed that higher doses led to reduced maternal body weight gain, increased foetal resorptions, and changes in organ function indicating toxicity.
- * Histological examinations revealed severe degenerative changes in the uterus, placenta, and vital organs of both mothers and foetuses, along with notable physical deformities in the foetuses such as skeletal malformations.
Long-term Outcomes of Surgically Treated Congenital Dislocation of the Knee.
J Pediatr Orthop
August 2024
Scottish Rite for Children, Dallas, TX.
Background: Congenital dislocation of the knee (CDK) may be idiopathic or associated with another condition, such as Larsen syndrome or arthrogryposis. Surgical reduction of type-3 dislocation may require quadricepsplasty (QP) or femoral diaphyseal shortening (FS). Because it is unknown which treatment is more effective, we evaluated long-term outcomes using patient-reported questionnaires and gait analysis, comparing results by surgery type and underlying diagnosis.
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