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E Pluribus, Unum: Emergent Redox Harmony from the Chaos of Blood Cells.
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Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA.
Blood cells play a fundamental role in maintaining systemic homeostasis, by responding dynamically to various physiological and environmental stimuli [...
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Ex Pluribus Unum: The CD4 T Cell Response against Influenza A Virus.
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April 2024
Immunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
Current Influenza A virus (IAV) vaccines, which primarily aim to generate neutralizing antibodies against the major surface proteins of specific IAV strains predicted to circulate during the annual 'flu' season, are suboptimal and are characterized by relatively low annual vaccine efficacy. One approach to improve protection is for vaccines to also target the priming of virus-specific T cells that can protect against IAV even in the absence of preexisting neutralizing antibodies. CD4 T cells represent a particularly attractive target as they help to promote responses by other innate and adaptive lymphocyte populations and can also directly mediate potent effector functions.
View Article and Find Full Text PDF[A MOLECULAR APPROACH TO DIAGNOSIS AND TREATMENT OF PEDIATRIC SOFT TISSUE SARCOMA FROM "E PLURIBUS UNUM" TO "EX UNO PLURES" AND BACK].
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November 2023
Pediatric Hematology-Oncology Department, Safra Pediatric Hospital, Sheba Medical Center, Ramat Gan, Israel.
Soft tissue sarcoma is a heterogeneous group of mesenchymal (fat, muscle, cartilage and blood vessel) tumors. It collectively comprises 1% of adult malignancies, and 7% of pediatric malignancies and according to the last WHO classification, contains over 50 histologic diagnoses. Due to its relatively infrequent occurrence, diversity of sub-types and high rates of inter-observer disagreement regarding the histological sub-type, the approach to both basic and clinical research, and, accordingly, treatment has traditionally been "one size fits all".
View Article and Find Full Text PDFE pluribus unum interpretable convolutional neural networks.
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Department of Computer Science and Biomedical Informatics, School of Science, University of Thessaly, Lamia, Greece.
The adoption of convolutional neural network (CNN) models in high-stake domains is hindered by their inability to meet society's demand for transparency in decision-making. So far, a growing number of methodologies have emerged for developing CNN models that are interpretable by design. However, such models are not capable of providing interpretations in accordance with human perception, while maintaining competent performance.
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