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Analysis of thyroid function and structure and serum metabolomics in pregnant rats exposed to airborne contaminants: Combined perchlorate, thiocyanate, and nitrate exposure.
Ecotoxicol Environ Saf
January 2025
School of Public Health, Xinjiang Medical University, Urumqi, China. Electronic address:
Objectives: Perchlorates, nitrates, and thiocyanates constitute environmental endocrine disruptors; however, health damage caused by absorption through the respiratory tract remains poorly studied. We investigated the effects of inhalation of these pollutants on thyroid function and structure and serum metabolomics in pregnant rats.
Methods: We established a Sprague-Dawley pregnant rat model exposed to perchlorate, nitrate, and thiocyanate at different gestational stages and compared maternal serum thyroid function levels, foetal development, thyroid morphology, and pathological changes between exposed and non-exposed groups at different concentrations.
Species- and tissue-specific profiles and potential risks of polychlorinated biphenyls (PCBs) and their metabolites in dogs and cats.
Sci Total Environ
January 2025
Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama, Ehime 790-8577, Japan. Electronic address:
In recent years, there has been growing concern about the long-term health effects of chemical exposure in pets, particularly dogs and cats, from sources such as pet food and house dust. Domestic cats (Felis silvestris catus) and dogs (Canis lupus familiaris) are continuously exposed to polychlorinated biphenyls (PCBs), with particular attention being paid to the toxicity of their metabolites, hydroxylated PCBs (OH-PCBs) and methylsulfonyl PCBs (MeSO-PCBs). However, the tissue distribution and species-specific differences of these PCB metabolites in domestic animals have not been fully elucidated.
View Article and Find Full Text PDFLong-chain perfluoroalkylether carboxylic acids PFO5DoA and PFO4DA alter glucose, bile acid, and thyroid hormone homeostasis in fetal rats from 5-day maternal oral exposure.
Environ Res
December 2024
U.S. Environmental Protection Agency, Office of Research & Development, Center for Public Health and Environmental Assessment, Research Triangle Park, NC, USA. Electronic address:
Chemical monitoring studies in North Carolina, USA and Shandong, China have reported detections of perfluoroalkylether carboxylic acids of increasing chain length with ether bonds between each fluorinated carbon. Despite detection there is limited hazard data available to inform risk assessment. Here, we exposed pregnant Sprague-Dawley rats to two of these compounds, perfluoro-3,5,7,9-butaoxadecanoic acid (PFO4DA) and perfluoro-3,5,7,9,11-pentaoxadodecanoic acid (PFO5DoA), from gestation days 18-22 across a series of doses (0.
View Article and Find Full Text PDFOrganic anion transporters in remote sensing and organ crosstalk.
Pharmacol Ther
November 2024
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine (Nephrology), University of California San Diego, La Jolla, CA 92093, USA. Electronic address:
Article Synopsis
- OAT1 and OAT3 are key transport proteins in the kidney that control the movement of drugs and metabolites, playing a critical role in homeostasis through the Remote Sensing and Signaling Theory (RSST).
- They act as hubs in a complex network that connects various biological systems, facilitating organ communication and regulating the levels of important biomolecules like urate and bile acids.
- Disturbances in OAT function due to medications can lead to significant drug interactions, and the RSST concept also applies to other transporters that manage similar processes.
Refractory amiodarone-induced thyrotoxicosis requiring adjunctive cholestyramine treatment.
BMJ Case Rep
September 2024
Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Amiodarone is an antiarrhythmic drug which may be associated with thyroid dysfunction. Type I amiodarone-induced thyrotoxicosis (AIT) is treated with thionamides and type II AIT is treated with glucocorticoids. Combined therapy is used in mixed or indeterminate forms.
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