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Article Synopsis
  • Vitamin A deficiency can lead to serious eye problems and is often linked to selective eating habits in children with autism spectrum disorder (ASD).
  • A study involving 13 children showed that many had significant neurological issues and obesity-related conditions due to low Vitamin A levels, with 61.5% of them also diagnosed with ASD.
  • Early identification of nutrient deficiencies through examining food intake is crucial for neuro-diverse children, as timely Vitamin A treatment can prevent long-term damage, including severe vision loss.
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The purpose of this study is to anatomically evaluate the impact on the patient intra vitam of an endocranial condition on a late 20th century skull housed in the Section of Legal Medicine of the University of Foggia (Foggia, Apulia, Italy). After performing a retrospective diagnosis, the condition is framed in the broader context of studies on this pathology. An anthropological and radiological analysis (X-ray and CT scan imaging) made it possible to confirm the preliminary information and to detail the osteological diagnosis of HFI.

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BACKGROUND Hyperostosis frontalis interna is a boney overgrowth of the inner side of the frontal bone of the skull caused by overgrowth of the endocranial surface. It is most often found in women after menopause. It is also associated with hormonal imbalance, being overweight, history of headaches, and neurocognitive degenerative conditions.

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Hyperostosis fronto-parietalis - radiology mimic of metastasis: A case report.

Radiol Case Rep

August 2021

Department of Radiology, Darlington Memorial Hospital, Hollyhurst Rd, Darlington, DL3 6HX, UK.

Hyperostosis frontalis interna (HFI) is a benign entity manifested by bony overgrowth in the frontal endocranial surface. It is most commonly reported incidentally among postmenopausal elderly women. Tracer uptake appearances of HFI can vary on planar bone scans, enabling it to be easily confounded with bone metastases.

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Objective: To re-analyze one of the oldest cases of malignant bone neoplasm with different analytical techniques.

Material: The available skeletal remains of grave 138 (G138) from the Iron Age necropolis of Münsingen-Rain (Switzerland, 420-240 BC).

Methods: The bones are analyzed by means of morphological, radiographic, histological, and biogeochemical methods.

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