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Cell polarity proteins promote macropinocytosis in response to metabolic stress.
Nat Commun
December 2024
Cancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Article Synopsis
- Macropinocytosis is a survival strategy used by cancer cells, especially in nutrient-poor environments, relying heavily on glutamine to sustain themselves, particularly in pancreatic ductal adenocarcinoma (PDAC) cells.
- The atypical protein kinase C (aPKC) enzymes, specifically PKCζ and PKCι, play a crucial role in regulating macropinocytosis by interacting with scaffold proteins that influence cell structure and function.
- The research shows that aPKCs enhance macropinocytosis through the relocation of Par3 to microtubules, and their depletion adversely affects cell viability, which can be reversed by restoring macropinocytosis, highlighting the significance of aPKCs in supporting
Nitric oxide synthase system in the brain development of neonatal hypothyroid rats.
Neuroscience
January 2025
Instituto Cajal, Avda. Doctor Arce, 24, 28002 Madrid, Spain.
Thyroid hormones play an important morphogenetic role during the fetal and neonatal periods and regulate numerous metabolic processes. In the central nervous system, they control myelination and overall brain development, regional gene expression, and regulation of oxygen consumption. Their deficiency in the fetal and neonatal periods causes severe mental retardation, due to lack of thyroid function, or to iodine deficiency.
View Article and Find Full Text PDFGenetic diversity of cytochrome P450 in patients receiving psychiatric care in Greece: a step towards clinical implementation.
Pharmacogenomics
August 2024
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, Alexandroupolis, 68100, Greece.
We herein inferred the genetic diversity of CYP450 isoenzymes to predict the percentage of patients who need dose adjustment in drugs used in psychiatry. Data of 784 Greek patients receiving psychiatric care who were genotyped for CYP2D6, CYP2C19, CYP1A2, CYP3A5 and CYP2C9 isoenzymes were inferred to gene-drug pairs according to the US FDA, Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group annotations and published literature. Atypical metabolism was found for 36.
View Article and Find Full Text PDFChildhood-related neural genotype-phenotype in ATP1A3 mutations: comprehensive analysis.
Genes Genomics
April 2024
Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Background: ATP1A3 is a gene that encodes the ATPase Na + /K + transporting subunit alpha-3 isoenzyme that is widely expressed in GABAergic neurons. It maintains metabolic balance and neurotransmitter movement. These pathways are essential for the proper functioning of the nervous system.
View Article and Find Full Text PDFInhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes.
Toxicol In Vitro
March 2024
Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address:
Purpose: The inhibitory effect of Apatinib on cytochrome P450 (CYP450) enzymes has been studied. However, it is unknown whether the inhibition is related to the major metabolites, M1-1, M1-2 and M1-6.
Methods: A 5-in-1 cocktail system composed of CYP2B6/Cyp2b1, CYP2C9/Cyp2c11, CYP2E1/Cyp2e1, CYP2D6/Cyp2d1 and CYP3A/Cyp3a2 was used in this study.
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