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Mice with 16p11.2 Deletion and Duplication Show Alterations in Biological Processes Associated with White Matter.
Int J Mol Sci
January 2025
Neuroscience and Mental Health Innovation Institute, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.
Deletion and duplication in the human 16p11.2 chromosomal region are closely linked to neurodevelopmental disorders, specifically autism spectrum disorder. Data from neuroimaging studies suggest white matter microstructure aberrations across these conditions.
View Article and Find Full Text PDFProtein phosphorylation and oxidative protein modification promote plant photosystem II disassembly for repair.
Plant Commun
December 2024
Department of Biochemistry and Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA. Electronic address:
The light-driven water-splitting reaction of photosystem II exposes its key reaction center core protein subunits to irreversible oxidative photodamage. A rapid repair cycle replaces the photodamaged core subunits in plants, but how the large antenna-core supercomplex structures of plant photosystem II disassemble for repair is not currently understood. Here, we report the specific involvement of phosphorylation in removal of the peripheral antenna from the core and monomerization of the dimeric cores.
View Article and Find Full Text PDFDirect observation of subunit rotation during DNA strand exchange by serine recombinases.
Nat Commun
November 2024
School of Molecular Biosciences, University of Glasgow, Bower Building, University Avenue, Glasgow, UK.
Article Synopsis
- * Using single-molecule FRET (smFRET) techniques, researchers provided direct evidence of this subunit rotation mechanism, observing fluctuations in FRET that align with the proposed model.
- * They measured rotation events in a timescale of 0.4-1.1 seconds, noting multiple recombination cycles and rapid rotation in the cleaved-DNA state without intermediate ligation during a ~25-second observation period.
Neurotrophin receptors of the Trk family are involved in the regulation of brain development and neuroplasticity, and therefore can serve as targets for anti-cancer and stroke-recovery drugs, antidepressants, and many others. The structures of Trk protein domains in various states upon activation need to be elucidated to allow rational drug design. However, little is known about the conformations of the transmembrane and juxtamembrane domains of Trk receptors.
View Article and Find Full Text PDFWe are still largely reliant on pesticides for the suppression of arthropod pests which threaten human health and food production, but the recent rise of evolved resistance among important pest species has reduced pesticide efficacy. Despite this, our understanding of strategies that effectively limit the evolution of resistance remains weak. Male-killing sex ratio distorting microbes (SRDMs), such as and , are common among arthropod species.
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