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Identification of catechin species using a colorimetric and fluorescence dual-mode sensor array based on peroxidase-like PtNi bunched nanoparticles.
Anal Methods
January 2025
Department of Chemistry, Capital Normal University, Beijing, 100048, China.
Catechins in tea, as promoters of human health, have attracted widespread attention. Herein, a dual-signal mode (colorimetric and fluorescence) sensor array for catechin species fingerprinting was built based on PtNi bunched nanoparticle (PtNi-BNP)--phenylenediamine (OPD)-HO system. PtNi-BNPs catalyze the reaction between OPD and HO to produce oxidized OPD (oxOPD) with both colorimetric (yellow) and fluorescent properties.
View Article and Find Full Text PDFA Fully Integrated ICP-Enriched and Nanozyme-Catalyzed Lateral Flow Assay for cfDNA Detection in Whole Blood.
Small
January 2025
Department of Chemistry, Fudan University, Shanghai, 200438, China.
Rapid and sensitive detection of Epstein-Barr virus cell-free DNA (EBV cfDNA) is crucial for early diagnosis and monitoring of nasopharyngeal carcinoma (NPC), but accessibility to screening is limited by complicated and costly conventional DNA isolation and purification approaches. Here, a fully integrated ion concentration polarization (ICP)-enriched and nanozyme-catalyzed lateral flow assay (ICP-cLFA) is developed, enabling total analysis of EBV cfDNA in whole blood samples, with DNA isolation, pre-concentration, and amplification performed on a microfluidic chip, consequently providing the signal readout within 75 min. Specifically, ICP preconcentration and amplification steps, together with target recognition catalyzed by a platinum-decorated mesoporous gold nanosphere (MGNS@Pt) nanozyme, result in an ultralow detection limit of 4 aM in standard cfDNA samples and 100 aM in whole blood from NPC-bearing rats.
View Article and Find Full Text PDFColored Cellulose Nanoparticles with High Stability and Easily Modified Surface for Accurate and Sensitive Multiplex Lateral Flow Assay.
ACS Nano
January 2025
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, P. R. China.
Decentralized testing using multiplex lateral flow assays (mLFAs) to simultaneously detect multiple analytes can significantly enhance detection efficiency, reduce cost and time, and improve analytic accuracy. However, the challenges, including the monochromatic color of probe particles, interference between different test lines, and reduced specificity and sensitivity, severely hinder mLFAs from wide use. In this study, we prepared polydopamine (PDA)-coated dyed cellulose nanoparticles (dCNPs@P) with tunable colors as the probe for mLFAs.
View Article and Find Full Text PDFChemical characteristics and bioactivity potential of polysaccharide extracts and purified fractions from Arctic brown macroalgae.
Carbohydr Polym
March 2025
Chemical Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula 403004, Goa, India.
Macroalgae growing in the polar regions are exposed to extreme environment conditions and may induce differences in the structural and bioactive properties of their polysaccharides. Six brown macroalgae viz. kelp species - Saccharina latissima, Laminaria digitata, and Alaria esculenta; rockweed Fucus distichus; and filamentous macroalgae - Chorda filum and Chordaria flageliformis, from the Arctic were investigated for polysaccharides and their bioactivity.
View Article and Find Full Text PDFCellulose nanofibers/polyacrylic acid hydrogels integrated with a 3D printed strip: A platform for screening prostate cancer via sarcosine detection.
Carbohydr Polym
March 2025
Department of Materials Science, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:
Cellulose nanofiber/polyacrylic acid (CNF/PAA) hydrogel-based colorimetric sensor was fabricated for non-invasive screening of prostate cancer (PCa) via selective detection of sarcosine. The hydrogel was synthesized by photo-crosslinking of acrylic acid in the presence of CNF which acted as mechanical reinforcement and as color enhancer. The hydrogel exhibited a high aqueous absorption and high mechanical strength.
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