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Inhaled methoxyflurane (Penthrox®) as a novel pain relief for outpatient hysteroscopy and other gynaecological procedures.
Eur J Obstet Gynecol Reprod Biol
November 2024
Birmingham Women's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2TG, UK; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Objective: Penthrox® (methoxyflurane) is a convenient, portable, self-administered disposable single-use handheld inhaler licenced as an emergency, rapid-onset, short-acting, analgesic in adult trauma patients. Outpatient hysteroscopy is one of the commonest procedures in contemporary gynecology but it can be associated with significant pain leading to poor patient experience and failed procedures. We evaluated the feasibility and acceptability of Penthrox® in women undergoing outpatient hysteroscopic procedures and its potential efficacy to reduce pain and improve patient experience.
View Article and Find Full Text PDFManaging acute pain with inhaled methoxyflurane in non-cancer patients: a review of the latest evidence.
Curr Opin Support Palliat Care
December 2024
Department of Emergency Medicine, Humber River Health, Toronto, Ontario, Canada.
Purpose Of The Review: Penthrox® (inhaled methoxyflurane, IMF) is an inhaled analgesic used for the treatment of moderate-to-severe acute pain. It has various advantages including the capacity for being self-administered in the presence of healthcare providers (HCPs), rapid onset and offset, and having documented evidence for minimal adverse events post-use. In a variety of non-oncological settings such as pre-hospital transport and minor outpatient procedures, amongst others, IMF has significantly reduced acute pain.
View Article and Find Full Text PDFPilot study to assess the feasibility of self-administered, low-dose methoxyflurane for cystoscopic procedures.
Can Urol Assoc J
August 2024
Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Introduction: Methoxyflurane (MEO F) (Penthrox™) is an inhaled, self-administered, non-opioid analgesic approved by Health Canada for the short-term relief of moderate to severe acute pain associated with trauma or interventional medical procedures. In this pilot study, we evaluated the feasibility of using MEOF as an anesthetic agent in 11 patients undergoing outpatient cystoscopic procedures.
Methods: The average duration of the procedure was 24 (range 20-35) minutes and this included 10 minutes of administration time of the drug and five minutes of wait time before the procedure.
Pain Self-Management with Inhaled Methoxyflurane by Emergency Department Trauma Patients: A Prospective, Interventional, Single-Center Study.
Int J Environ Res Public Health
June 2023
IAME "Infection, Antimicrobials, Modelling, Evolution" Research Unit, INSERM UMR1137, University of Paris Cité, 75018 Paris, France.
Article Synopsis
- The study aimed to evaluate the effectiveness of self-administered low-dose methoxyflurane on managing trauma pain in patients outside the emergency department during the COVID-19 pandemic at Bichat University Medical Center in Paris.
- It involved two groups: a control group receiving standard pain management and an intervention group using methoxyflurane alongside standard treatments.
- Results showed both groups reported lower pain levels over time, with the intervention group experiencing a greater reduction between specific time points, indicating methoxyflurane may enhance pain relief in similar patients.
Literature review on the use of methoxyflurane in the management of pain in cancer-related procedures.
Support Care Cancer
March 2023
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Introduction: Self-administered methoxyflurane, also known as Penthrox, at a sub-anesthetic dose is a short-term, fast-acting, and safe analgesic that may provide suitable pain relief for cancer patients. This review aims to compile the existing evidence on methoxyflurane and its efficacy in reducing pain during cancer-related procedures.
Methods: A literature search was conducted through OVID Medline and Embase.
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