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Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for Infection.
Pharmaceuticals (Basel)
December 2024
Department of Biochemistry, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Infection with the protozoan parasite causes human Chagas disease. Benznidazole (BNZ) and nifurtimox are the current drugs for the treatment; however, they induce severe adverse side effects in patients; therefore, there is a need to improve the treatment effectiveness and efficiency of these drugs for its safer use. : Glyburide, glipizide, and gliquidone, hypoglycemic drugs for diabetes treatment, were previously predicted to bind to dihydrofolate reductase-thymidylate synthase from by in silico docking analysis; they also showed antiproliferative effects against epimastigotes, the stage of the insect vector.
View Article and Find Full Text PDFFabrication of glipizide loaded polymeric microparticles; in-vitro and in-vivo evaluation.
PLoS One
January 2025
Faculty of Pharmacy, Sardar Bahadur Khan Women University Quetta, Quetta, Pakistan.
Controlled-release microparticles offer a promising avenue for enhancing patient compliance and minimizing dosage frequency. In this study, we aimed to design controlled-release microparticles of Glipizide utilizing Eudragit S100 and Methocel K 100 M polymers as controlling agents. The microparticles were fabricated through a simple solvent evaporation method, employing various drug-to-polymer ratios to formulate different controlled-release batches labeled as F1 to F5.
View Article and Find Full Text PDFManaging high disease burden: a study of medication rationality in diabetes and hypertension in Andhra Pradesh.
J Diabetes Metab Disord
December 2024
Aditya Pharmacy College, Surampalem, Andhra Pradesh India.
Objectives: To assess the burden of chronic Non-communicable diseases (NCDs) such as diabetes and hypertension, and evaluate the utilization of drugs for their treatment among the population of Andhra Pradesh, India.
Methods: A cross-sectional study was conducted to analyse the prevalence of diabetes and hypertension, as well as the pattern of drug usage for their management. Data were collected through surveys and medical records review.
Stability Development, Optimization and Evaluation of Gastro-Retentive Microspheres of Antidiabetic Agent by Full Factorial Design.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
August 2024
Associate Professor, Department of Pharmacology, DCS's A.R.A. College of Pharmacy, Nagaon, Dhule (MS) India.
Objective: This work is aimed to Formulate, Optimize and Evaluate Gastro-Retentive Microspheres of Antidiabetic Agent by Full Factorial Design.
Methods: Microspheres were prepared using Emulsification-cross linking technique. To this HPMC-K4M and Carbopol was dissolved in 250 ml of water and allowed to swell for 24 hr at room temperature.
In silico study suggests potential drugs that target CD151 to treat breast cancer and glioblastoma.
J Comput Chem
December 2024
Laboratory for the Design and Development of New Drugs and Biotechnological. Innovation, SEPI-Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
Recently tetraspanin CD151 has been identified as an important biological target involved in metastatic processes which include cell adhesion, tumor progression processes, and so forth in different types of cancers, such as breast cancer and glioblastoma. This in Silico study considered 1603 compounds from the Food and Drug Administration database, after performing an ADMET analysis; we selected 853 ligands, which were used for docking analysis. The most promising ligands were selected from docking studies, based on two criteria: (a) showed lowest affinity to the CD151 protein and (b) they interact with the QRD motif, located in the second extracellular loop.
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